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Epigenetic changes induced by obesity and their heredity
Roušová, Lucie ; Skálová, Lenka (advisor) ; Boušová, Iva (referee)
Obesity, a chronic disease characterized by the deposition of excessive amounts of fat in the body, is the cause of the development of many other comorbidities. In recent years, this disease appears in ever younger people. Both genetic and environmental factors are involved in the development of obesity. The link between these two factors could be epigenetic modifications. Epigenetic changes are changes in a person's phenotype without changing their genotype. These changes, which include DNA methylation and histone modification, thus affect gene expression and function, without altering the DNA sequence. The aim of my bachelor thesis was to search out which epigenetic changes are associated with obesity and what genes are affected in this way. I focused on the changes that obesity causes, but also on the changes that cause obesity. I also tried to find information about whether these genome modifications are hereditary and how many generations are possibly affected by them. From the available information, it is clear that there are a lot of epigenetic modifications that are somehow associated with obesity. For example, the changes in proopiomelanocortin, tapsin or insulin like growth factor 2 genes have been detected. Some modifications are associated with paternal obesity (e.g. the...
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