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Delivery of protein or peptide into the skin using cubosomes and microneedles
 Pekáčová, Simona ; Pávek, Petr (advisor) ; Holas, Ondřej (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Simona Pekáčová Supervisor: Prof. PharmDr. Petr Pávek, Ph. D. Title of diploma thesis: Delivery of protein or peptide into the skin using cubosomes and microneedles Transdermal transport of high-molecular-weight and hydrophilic substances is complicated by the protective skin layer, the stratum corneum. Physical breaching of this layer using microneedles combined with penetration- enhancing properties of cubosomes was previously reported as an effective approach to transdermal drug delivery and therefore employed in this project. (Rattanapak et al. 2012) Delivering abilities of solid (600 µm), coated (500, 600, 750 µm) and hollow (450, 600 µm) MNs were compared with intradermal injection by hypodermic needle. Cubosomes were prepared from phytantriol, poloxamer 407 and propylene glycol using liquid precursor method and loaded with fluorescent ovalbumin (FL-OVA) or SIINFEKL-TAMRA (ST) peptide. Several formulations for coating of solid microneedles were prepared using various solvents and excipients to investigate quality of coatings and their ability to deliver the drug into skin. Polyvinyl alcohol (PVA) turned out to be the most efficient coating excipient providing equally spread...
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