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Autoantibodies against cancer-retina antigens in the serum of melanoma patients
Niebauerová, Iva ; Drahošová, Marcela (referee) ; Jílek, Petr (advisor)
An investigation presented in this thesis was concerned in production of cancer- retina proteins and the study of autoantibody reaction against them in the sera of melanoma patients. The photoreceptor genes and transcripts (mRNA) are presented not only in the photoreceptor cells, but they also occure in other tissues of neuroectodermal origin - melanocytes, melanoma, pineal glands and some other tumor cells (small cell lung carcinoma). The specific photoreceptor proteins are normally expressed only in photoreceptor cells, but in case of melanoma and other tumor cells, they can be also detected [Bazhin et al., 2006]. If photoreceptor proteins are produced outside the neuroimmunoprivileged zone, they provoke autoantibody reactions and the immune system recognizes them as antigens. By some oncologic patients it was even observed a damage of retinal cells, rods and cones, which was based on the destructive reaction of autoantibodies against photoreceptor proteins. This kind of disease belongs to the group of paraneoplastic syndromes, disorders which are connected to cancer presence in organism, but not caused by tumor itself. In this case we are talking about MAR (melanoma associated retinophaty) and CAR (carcinoma associated retinopathy) [Bazhin et al., 2007]. The photoreceptor proteins, I was working...
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