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The effect of dietary prebiotic supplementation on neonatal development in rats
Medveďová, Martina ; Doleželová, Eva (advisor) ; Kovařík, Miroslav (referee)
Charles University, Faculty of Pharmacy in Hradec Králové, Department of Biological and Medical Sciences University of Barcelona, Faculty of Pharmacy and Food Science, Department of Biochemistry and Physiology Student: Martina Medveďová Supervisor: PharmDr. Eva Doleželová, Ph.D. Consultant: Dr. Francisco José Pérez Cano, Ph.D. Study program: Pharmacy Title of diploma thesis: The effect of dietary prebiotic supplementation on neonatal development in rats Human breast milk is considered a gold standard in infant nutrition due to its multiple evident benefits on human health. However, breastfeeding is not always possible for various reasons; thus, it is a huge challenge to provide infant formulae which best mimic the composition and effects of human milk. Prebiotics added to infant formulae may greatly contribute to these prospective notable improvements in infant nutrition. The aim of this study was to evaluate the effect of a novel dietary prebiotic supplementation (under patent) on growth, fecal consistency, and immune maturation in suckling rats. G14 Lewis suckling rats were distributed into 2 experimental groups (n = 21/group): reference and prebiotic group. Vehicle or the prebiotic was administered by oral gavage daily from day 2 to 16 of life. Animals were weighed daily and their size and...
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