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New strategies in pharmacotherapy and prevention of migraine
Kovaříková, Gabriela ; Červený, Lukáš (advisor) ; Vokřál, Ivan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Gabriela Kovaříková Supervisor: doc. PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: New strategies for the treatment and prevention of migraine Abstract: Migraine is a severe neurological disease, which has many subtypes. Migraine affects patient's physical and mental well-being and also work and family relationships. Migraine manifests as characteristic pain accompanied by vomiting and nausea or other symptoms. The first part of this paper deals with the current knowledge on pathophysiology of migraine, factors which affect migraine, degree of heritability, and specifics of chronic migraine. Diagnosis of migraine is also included and that based on MIDAS questionnaire are addressed in the diploma thesis. The second part is devoted to the therapy of acute attacks and prophylaxis of migraine, describes drugs used in these indications, characterizes them in more detail and lists their limitations. This section also outlines new pathophysiological findings and molecules that may receive future attention. New biological therapies and progress in terms of monoclonal antibody registration are also described. Nonpharmacological strategies for migraine treatment are mentioned as well. In addition, the...
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