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Antitumour efficacy of gels containing liposomes with hydroxy-aluminium phthalocyanine in photodynamic therapy
Kobrle, Pavel ; Poučková, Pavla (advisor) ; Štukavec, Jan (referee)
The targets of the diploma thesis presented here were to establish the antitumour efficacy of a new liposomal product with hydroxy-aluminium phthalocyanine (PC) in photodynamic therapy (PDT) of malignant tumours and determine the optimum time interval between the topical application of the product and PDT (tumour exposure to light). Effects were examined of the PC concentration on the PDT efficacy in a colon carcinoma cell line (SW-620), mammary carcinoma cell line (MDA-MB-231) and human neuroblastoma cell line (UKF NB-3). Hydroxy-aluminium phthalocyanine was employed as a photosensitizer. Outbred athymic female nude CD-1 mice already bearing the above mentioned xenotransplanted tumours were used in the experiments. The area comprising the tumour was exposed to light from a xenon lamp (600-700 nm, 80 J/cm2 ). The results were statistically evaluated, summarized in tables and plotted in graphs. In the diploma work, the liposomal product containing phthalocyanine (9-18 mg/ml) was shown to have considerable antitumour effects in the types of tumours chosen. The optimum time interval for the PDT is of 10 min after the product topical application. Key words: photodynamic therapy; hydroxy-aluminium phthalocyanine; liposomal drug delivery
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Taxation of income from employment and emoluments
Kobrle, Petr ; Karfíková, Marie (advisor) ; Karfíková, Marie (referee)
Income taxation from employment and function benefits The diploma thesis concerns with the legal form of income taxation from employment and function benefits. The introductory part of the thesis lines out the tax system in the Czech Republic and it puts the natural person income tax from employment and function benefits in its frame. This part is also intended to explain individual tax construction elements and other important tax terms. In the major part of the thesis, the author follows the Income Tax Act's scheme in substantial features: he deals with the "employment" and "function benefits" terms from the point of view of the valid rule of law and the constant practice of the courts. After the terms definition, the author displays the employee taxation current legal form. In detail, he works out two issues, i.e. the exemption from the object of the tax and tax exemption, and gives examples from the application practice represented by adjudications and opinions of The Ministry of Finance of the Czech Republic. He deals with the income tax from employment and function benefits specific base construction, that was put into practice in the Czech Republic on 1.1.2008, and with the linear tax rate introduced on the same date in the frame of a fiscal reform. Nontaxable parts of the tax base, tax abatement and...
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Cause of mechanical vibrations of Palašer synchronous motors and its removal
Pavelka, J. ; Šimek, J. ; Kobrle, P. ; Kokeš, Petr
The paper describes the procedure and the result of analysis of mechanical vibrations of mining machines at the Palašer mine in the Russian Federation. The cause of these vibrations was the change in the magnitude of the magnetic flux in the air gap. The simulations showed the possibility of eliminating these changes in\nmagnetic flux by injecting suitable voltages into the stator windings. The implementation of this injection is further described by torque variable component feed-direct compensation. Finally, oscillography records are presented before and after injection.
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Antitumour efficacy of gels containing liposomes with hydroxy-aluminium phthalocyanine in photodynamic therapy
Kobrle, Pavel ; Poučková, Pavla (advisor) ; Štukavec, Jan (referee)
The targets of the diploma thesis presented here were to establish the antitumour efficacy of a new liposomal product with hydroxy-aluminium phthalocyanine (PC) in photodynamic therapy (PDT) of malignant tumours and determine the optimum time interval between the topical application of the product and PDT (tumour exposure to light). Effects were examined of the PC concentration on the PDT efficacy in a colon carcinoma cell line (SW-620), mammary carcinoma cell line (MDA-MB-231) and human neuroblastoma cell line (UKF NB-3). Hydroxy-aluminium phthalocyanine was employed as a photosensitizer. Outbred athymic female nude CD-1 mice already bearing the above mentioned xenotransplanted tumours were used in the experiments. The area comprising the tumour was exposed to light from a xenon lamp (600-700 nm, 80 J/cm2 ). The results were statistically evaluated, summarized in tables and plotted in graphs. In the diploma work, the liposomal product containing phthalocyanine (9-18 mg/ml) was shown to have considerable antitumour effects in the types of tumours chosen. The optimum time interval for the PDT is of 10 min after the product topical application. Key words: photodynamic therapy; hydroxy-aluminium phthalocyanine; liposomal drug delivery
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Taxation of income from employment and emoluments
Kobrle, Petr ; Karfíková, Marie (advisor) ; Karfíková, Marie (referee)
Income taxation from employment and function benefits The diploma thesis concerns with the legal form of income taxation from employment and function benefits. The introductory part of the thesis lines out the tax system in the Czech Republic and it puts the natural person income tax from employment and function benefits in its frame. This part is also intended to explain individual tax construction elements and other important tax terms. In the major part of the thesis, the author follows the Income Tax Act's scheme in substantial features: he deals with the "employment" and "function benefits" terms from the point of view of the valid rule of law and the constant practice of the courts. After the terms definition, the author displays the employee taxation current legal form. In detail, he works out two issues, i.e. the exemption from the object of the tax and tax exemption, and gives examples from the application practice represented by adjudications and opinions of The Ministry of Finance of the Czech Republic. He deals with the income tax from employment and function benefits specific base construction, that was put into practice in the Czech Republic on 1.1.2008, and with the linear tax rate introduced on the same date in the frame of a fiscal reform. Nontaxable parts of the tax base, tax abatement and...
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