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Disseminated Intravascular Coagulation Syndrome in Critical Care
Kasperová, Jana ; Krška, Zdeněk (referee) ; Kvasnička, Jan (advisor)
We have conducted a retrospective study on disseminated intravascular coagulation syndrome (DIC) in critical care. The theoretical part of the study focusses on the epidemiology, pathogenesis, ethiology, clinical features, laboratory diagnosis, differential diagnosis, and medical complications of the disseminated intravascular coagulation syndrome, and describes the major therapeutic approaches. The aim of this study is to determine the etiology and outcome of the treatment of 29 patients hospitalized because of a DIC diagnosis in General University Hospital in Prague between January 2006 and December 2009, to analyse the changes of the laboratory test values over time, to see if there is any correlation between the chosen variables, and to assess confidence in the diagnosis of DIC according to the ISTH criteria for the diagnosis of DIC. The hypotheses that there will not be a significant difference between the gender, age and the laboratory values of DIC patients, that the mortality of septic patients with DIC will be a minimum of 50 %, and that the correlation between age, gender and the laboratory values in DIC patients will not be significant, were confirmed. On the contrary, the hypothese that the platelet count of all the DIC patients will be smaller or equal to 100 x 109 /l, prothrombin time (INR)...
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