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Synthesis of substituted arylguanidines as potential drugs X.
Jarešová, Dominika ; Palát, Karel (advisor) ; Vinšová, Jarmila (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Author: Dominika Jarešová Supervisor: PharmDr. Karel Palát, CSc. Title of diploma thesis: Synthesis of substituted arylguanidines as potential drugs X. The increasing frequency of diseases caused by tuberculosis and pathogenic fungi leads to high mortality especially of immunocompromised patients. Therefore it is necessary to find new substances with anti-mycobacterial and antifungal activity. Series of on the ring substituted phenylguanidines were synthetized in this diploma thesis, specifically [5-methyl-(2-tetradecylsulfanyl)phenyl]guanidines with the change of substituents on guanidine group and 1,1-dimethyl-3-[4-(pentadecylsulfanyl)fenyl] guanidine. The oxidation of [(4-oktylsulfany)fenyl]guanidinium-nitrate was done. Substances were tested against series of pathogenic fungi and genus Mycobacterium. Products were synthetized in the four-step synthesis. Alkylarylsulfides were prepared by the reaction between alkylthiols and 4-chloro-3-nitrotoluene or p-chloronitrobenzene with active copper as a catalyst in the first step. The nitro group on the ring was reduced to amino group by the reaction with stannous chloride under nitrogen atmosphere in the second step. Sulfanylphenylamines were then...
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Women coming to the office of Charles University (20's 20th century)
Jarešová, Dominika ; Sekyrková, Milada (advisor) ; Brádlerová, Daniela (referee)
This bachelor thesis deals with the arrival of women in the office of the Charles University during the first years of independant Czechoslovakia. Based on a comparison of period publications, secondary literature, and subsequent analysis of the archival sources of the Charles University, the aim is to map when and under what circumstances women entered the Charles University office. An analysis of the personal files of clerks leads this work to the conclusion that the first women enroll at Charles-Ferdinand University at the end of the Austro-Hungarian Empire. The thesis describes the positions in which officials worked, what their working life was like, and what their career opportunities were. The bachelor thesis is divided into three main chapters. The first of them focus on social changes in the status of women during the 19th century and at the beginning of the 20th century, the second chapter deals with the office of the Charles-Ferdinand and then the Charles University and the arrival of the first women as officials, the third chapter is devoted exclusively to officials of Zdeňka Čacká. Keywords: Charles-Ferdinand University, Charles University, gender, women's emancipation, office, clerk, late 19th century and early 20th century, Zdeňka Čacká.
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Synthesis of substituted arylguanidines as potential drugs X.
Jarešová, Dominika ; Palát, Karel (advisor) ; Vinšová, Jarmila (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Author: Dominika Jarešová Supervisor: PharmDr. Karel Palát, CSc. Title of diploma thesis: Synthesis of substituted arylguanidines as potential drugs X. The increasing frequency of diseases caused by tuberculosis and pathogenic fungi leads to high mortality especially of immunocompromised patients. Therefore it is necessary to find new substances with anti-mycobacterial and antifungal activity. Series of on the ring substituted phenylguanidines were synthetized in this diploma thesis, specifically [5-methyl-(2-tetradecylsulfanyl)phenyl]guanidines with the change of substituents on guanidine group and 1,1-dimethyl-3-[4-(pentadecylsulfanyl)fenyl] guanidine. The oxidation of [(4-oktylsulfany)fenyl]guanidinium-nitrate was done. Substances were tested against series of pathogenic fungi and genus Mycobacterium. Products were synthetized in the four-step synthesis. Alkylarylsulfides were prepared by the reaction between alkylthiols and 4-chloro-3-nitrotoluene or p-chloronitrobenzene with active copper as a catalyst in the first step. The nitro group on the ring was reduced to amino group by the reaction with stannous chloride under nitrogen atmosphere in the second step. Sulfanylphenylamines were then...
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