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Synthesis of cycles using organocatalysis and catalysis with metal complexes
Hurný, David ; Veselý, Jan (advisor) ; Trnka, Tomáš (referee)
This thesis deals with an enantioselective synthesis of cyclic compounds by using a combination of organocatalysis and transition metal catalysis. The thesis deals mainly with usage of aminocatalyst for activation of aldehydes and copper catalyst for activation of terminal triple bond. The first part is focused on the preparation of starting compounds for cyclizations (α-oxoesters, α- substituted nitroalkanes and α-substituted aldehydes). The second part concerns carbocyclization itself and optimization of reaction conditions to achieve highly stereoselective reaction. Powered by TCPDF (www.tcpdf.org)
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Textbook of organic chemistry for secondary education.
Hurný, David ; Hybelbauerová, Simona (advisor) ; Klímová, Helena (referee) ; Smrček, Stanislav (referee)
This thesis deals with creation of new textbook for high schools and gymnasium students. The main focus of this work is mainly on general prinicples and laws in chemistry. Great attention is dediacted to atom structure,chemical bond, electronic effects, resonance theory, induction and mesomeric effect. The core content based on RVP is supplemented by parts for work with talented students. Every chapter is supplemented with number of excercises which should be used to complement the subject matter. Powered by TCPDF (www.tcpdf.org)
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Synthesis of cycles using organocatalysis and catalysis with metal complexes
Hurný, David ; Veselý, Jan (advisor) ; Trnka, Tomáš (referee)
This thesis deals with an enantioselective synthesis of cyclic compounds by using a combination of organocatalysis and transition metal catalysis. The thesis deals mainly with usage of aminocatalyst for activation of aldehydes and copper catalyst for activation of terminal triple bond. The first part is focused on the preparation of starting compounds for cyclizations (α-oxoesters, α- substituted nitroalkanes and α-substituted aldehydes). The second part concerns carbocyclization itself and optimization of reaction conditions to achieve highly stereoselective reaction. Powered by TCPDF (www.tcpdf.org)
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