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Vliv střevní mikroflóry na endotoxinový šok
Hrnčíř, Tomáš ; Kobayashi, K. ; Flawell, R. A. ; Hudcovic, Tomáš ; Kozáková, Hana ; Štěpánková, Renata ; Tlaskalová, Helena
Endotoxin shock is the most severe complication of sepsis. Lipopolysaccharide (LPS) or endotoxin, a structural component of gram negative bacteria, is a major effector and can activate the innate immune system and lead to multiple organ failure, termed endotoxin shock. In our project we study the effect of intestinal microflora on the susceptibility to endotoxin using a model of germ-free and specific pathogen free mice
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Slizniční imunita, střevní mikroflora a nespecifické střevní záněty
Tlaskalová, Helena ; Štěpánková, Renata ; Sokol, Dan ; Rossmann, Pavel ; Cukrowska, Božena ; Hudcovic, Tomáš ; Tučková, Ludmila ; Kozáková, Hana ; Řeháková, Zuzana ; Hrnčíř, Tomáš ; Drastich, Pavel ; Frolová, Lenka ; Powrie, F. ; Uhlig, H. ; Bland, P. W.
Etiological role of intestinal microflora and abberant function of mucosal immunity in development of inflammatory bowel disease is discussed. Animal models of human IBD are described and characterized
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Mucosal immunity, intestinal microflora and inflammatory bowel disease (IBD)
Tlaskalová, Helena ; Štěpánková, Renata ; Powrie, F. ; Tučková, Ludmila ; Sokol, Dan ; Funda, David P. ; Rossmann, Pavel ; Cukrowska, Božena ; Hudcovic, Tomáš ; Kozáková, Hana ; Řeháková, Zuzana ; Hrnčíř, Tomáš ; Drastik, p. ; Smetana, K. ; Frolová, Lenka
The interface between the organism and the outside world, which is the site of exchange of nutrients.
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