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Online marketingová komunikace vybrané společnosti
Horák, David
The bachelor thesis deals with the online marketing communication of a selected company and its goal is to propose a plan of marketing communication for this company. The proposal of the plan constitutes of specific recommendations, that should raise awareness of the company, attract new customers and support the loyalty of present customers. The proposal is based on current trends in the field of online marketing and best practices compiled in literature research. Current state of marketing communication, available data in Google Analytics, Google Ads and Meta Business Suite, SWOT analysis and external analysis were taken into consideration while making this proposal. A survey about ROPO effect is also part of the thesis. Its goal is to assess influence of this effect on the selected company, or rather on its online promotion.
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Návrh interiéru hospody s loveckou a mysliveckou tématikou
Horák, Dominik
The topic of this work is the design of a public interior of a pub with hunting themes. Part of this work is the design of the space, which is located in the smaller town of Úštěk in northern Bohemia. This town lies between the two district towns of Litoměřice and Česká Lípa. This space is located in an older building on the main road, near the central square. It currently serves as a restaurant. Since this is an old realization, I decided to revive this space with my solution of the interior design of this building. The specific space is the main room and the adjoining rooms of the restaurant. A part of this draft is also a new solution of adjacent toilets.
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Minimally Invasive Approaches in the Treatment of Coronary Artery Disease
Horák, David ; Bernat, Ivo (advisor) ; Ošťádal, Petr (referee) ; Mates, Martin (referee)
Cardiac catheterization performed via the distal radial artery (DRA) from the anatomical snuffbox or distal dorsal radial access is a new method of arterial access. Compared to the conventional radial approach (cTRA), it offers some advantages including a significant reduction in postprocedural radial artery occlusion (RAO), reduction in the time required for hemostasis, and reduction in bleeding complications and their severity. This method facilitates the use of the non-dominant, left upper limb (LUE) even for operators accustomed to approaching catheterization from the right UE. OBJECTIVES: 1) To introduce the distal radial artery approach (dTRA) in cardiac catheterization for patients with suspected or known coronary artery disease. 2) To optimize the system of post-procedural care after surgery from the distal radial artery. 3) To demonstrate the utility of the left distal radial approach in routine clinical practice. 4) To demonstrate the benefit of routine use of ultrasound-guided distal radial artery punctures. METHODS AND RESULTS: 1) We screened 75 patients suitable for catheterization via the DRA route in a pilot project. Based on ultrasound criteria, 55 patients were included. Of these, 46(84%) were successfully catheterized. 91% of procedures were performed from the left, non-dominant...
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Avian communities of overgrown wetlands near fishponds in the Třeboň basin
Tuháček, Filip ; Hořák, David (advisor) ; Voříšek, Petr (referee)
Wetlands are one of the most unique and threatened biotopes on earth. Encroachment, mainly due to the cessation of traditional management leads to the appearance and spread of shrubs (mostly willows, Salix spp.). ey eventually change the appearance of the wetlands into forest- like habitats. is diploma thesis describes avian communities of overgrown wetlands and compares them with those of non-overgrown wetlands, i.e., reedbeds and low vegetation (mainly sedges, Carex spp.). Although the overgrown wetlands did not have the lowest species and population densities, in comparison with non-overgrown wetlands, the densities of wetland specialists and endangered species, such as Savi's Warbler (Locustella luscinioides), Bluethroat (Luscinia sve- cica), and Water Rail (Rallus aquaticus) were lowest in the willow-dominated wetland compared to non-overgrown. Due to the overgrowth of the wetland, the avian communities are more wo- odland and common bird species, such as Common Chiffchaff (Phylloscopus collybita), Willow Warbler (Phylloscopus trochilus), and Great Tit (Parus major). We also wanted to investigate and compare the invertebrate biomass in overgrown and non-overgrown wetlands. We wanted to find out how avian communities depend on the food resources in wetlands around the South Bohemian fish ponds....
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Spatio-temporal activity of African ungulates at water sources in Mogalakwena River Reserve, South Africa
Homoláč, David ; Hořák, David (advisor) ; Bennitt, Emily (referee)
The large mammals of African savannah are a well-studied group of animals, but few studies focus on the temporal, circadian activity of this group of mammals. Such studies either use problematic methods of data collection (webcams, direct observations) or have been conducted in national parks or large reserves, where movement of the animals is not limited with anthropogenic structures. In such sites, the community of large mammals is usually complete, including the guild of large carnivores. Thus, small, fenced off reserves without a complete community of large mammals are understudied. Therefore, this work focuses on the spatio-temporal activity of ungulates at water sources in the Mogalakwena River Reserve in South Africa, which is an example of a reserve without large predators except the leopard (Panthera pardus). I used camera traps to assess the activity of ungulates, which I placed alongside the Mogalakwena River and at the water holes. With the help of artificial intelligence, I classified the photos to the level of activity of each species. I then tested this activity over space (type of water source) and against biotic and abiotic factors. The activity of ungulates at water sources is influenced by the maximum daily temperature, as the activity shifts to the evening hours during higher...
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Exceptions to the positive relationship between species diversity and environmental heterogeneity
Srpová, Tereza ; Hořák, David (advisor) ; Divíšek, Jan (referee)
The positive relationship between environmental heterogeneity and species richness has been taken for granted for many years. However, recent studies have revealed possible alternatives to this positive relationship, such as negative or unimodal relationship. There are many possible explanations for these alternative relationships. Increasing spatial heterogeneity of a biotope of a given size inevitably leads to reduction in the effective area available to the organisms inhabiting it. At the same time, increased environmental heterogeneity can lead to fragmentation and isolation of biotope patches, which can have negative consequences for the species richness of the community. Inadequate methodology may be one of the reasons why these alternative relationships have only been discovered in the recent years. Correct information on the relationship between environmental heterogeneity and species richness is essential for decisions on biodiversity conservation. For this reason, it is necessary to discover such alternative relationships in specific ecosystems, which we aim to protect, and to always take them into account, even if they are less common.
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Aesthetical value of environmental heterogeneity
Bufka, Ondřej ; Hořák, David (advisor) ; Janečková Molnárová, Kristina (referee)
Throughout their lives, people are in constant contact with the natural environments that surrounds them. The aesthetic value of this environment has a great infuence on man's relationship with it. There is also a connection between the aesthetic value of the environment and it's heterogeneity. Environmental heterogeneity includes physical, topographical and also biodiversity of the environment. It is also an important factor influencing it's ecological and aesthetic value. High levels of heterogeneity in a landscape can have a positive impact on biodiversity, resistance against disturbances and also on people's aesthetic preferences. Positive effects resulting from people's contact with visually attractive landscapes can further motivate them to protect and conserve nature and even improve their mental health. The aesthetic value of the environmental heterogeneity therefore has a great, but not yet fully exploited, potential for nature conservation and landscape management.
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Population trends of wetland birds in Europe
Karasová, Lucia ; Hořák, David (advisor) ; Musil, Petr (referee)
Waterbird research has grown in importance over the decades, attracting both professional and public interest due to its fascinating nature. Historical records of waterbird abundance have allowed the analysis of population trends and the identification of potential aberrations. Europe is an important region for many breeding and wintering species, providing a wide range of suitable habitats throughout the year. Several wildfowl and diver species, but also common waders, wading birds or cormorants exhibited a long-term stable or increasing population trends. The most decreasing trends were reported for some diving ducks, grebes and grassland-nesting waders. Despite reports of apparent declines in waterbird populations, the identification of ecological causes is complex due to the diverse characteristics of different waterbird species, making this a broad and complex topic to investigate. From the mentioned ecological drivers, habitat loss has the most negative impact on waders, whilst climate change could be associated with the shifting of breeding and wintering ranges. The birds breeding on wet grasslands were mostly affected by modern agriculture, and nowadays, their populations are threatened. KEYWORDS wetland birds, non-passerines, population dynamics, Europe, conservation biology
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Temoporfin-conjugated upconversion nanoparticles for NIR-induced photodynamic therapy of pancreatic cancer
Shapoval, Oleksandr ; Větvička, D. ; Kabešová, M. ; Engstová, Hana ; Horák, Daniel
Photodynamic therapy (PDT), a clinically approved cancer treatment strategy, has the potential to cure pancreatic cancer with minimal side effects. PDT primarily uses visible wavelengths to directly activate hydrophobic photosensitizers, which may be insufficient for deep-seated cancer cells in clinical practice due to poor penetration. Upconversion nanoparticles (UCNPs) serve as an indirect excitation source to activate photosensitizers (PSs) in the NIR region, overcoming the limitations of molecular PSs such as hydrophobicity, non-specificity, and excitation in the UV/Vis region. Here, monodisperse upconversion NaYF4:Yb3+, Er3+, Fe2+ nanoparticles (UCNPs) have been surface-engineered with poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (mTHPC), a clinically used PDT prodrug, for near-infrared (NIR) light-triggered PDT of pancreatic cancer. The incorporation of Fe2+ ions into the particles increased the fluorescence intensity in the red region matching the activation wavelength of mTHPC. Covalent binding of mTHPC to the surface of UCNP@PMVEMA particles provided colloidally stable conjugates enabling generation of singlet oxygen. In vitro cytotoxicity and photodynamic activity of the particles were evaluated using INS-1E rat insulinoma and Capan-2 and PANC-01 human pancreatic adenocarcinoma cell lines. The PDT efficacy of UCNP@PMVEMA-mTHPC conjugates after irradiation with 980 nm NIR light was tested in vivo in a pilot study on Capan-2 human pancreatic adenocarcinoma growing subcutaneously in athymic nude mice. The intratumoral administration of the nanoconjugates significantly hindered tumor growth and demonstrated promising PDT efficacy against human pancreatic cancer.
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Magnetic nanoparticles with antibacterial properties: Synthesis, characterization and biological applications
Shatan, Anastasiia-Bohdana ; Horák, Daniel (advisor) ; Kaman, Ondřej (referee) ; Matějíček, Pavel (referee)
In response to the escalating global threat of antibiotic resistance, innovative strategies are imperative. This thesis focuses on surface-engineered magnetic nanoparticles (MNPs) with potent antibacterial properties, aiming to combat antibiotic resistance effectively. Specifically, uniform 16-nm Fe3O4 nanoparticles were synthesized via oleic acid-stabilized thermal decomposition of Fe(III) oleate in a high-boiling organic solvent. Optionally, 8-nm γ-Fe2O3 particles were obtained by coprecipitation of Fe2+ and Fe3+ salts in a basic medium. For the application of antibacterial MNPs in biological media, water-dispersible nanoparticles were required. Hence, original magnetic particles containing hydrophobic oleic acid (OA) coating were modified with silica using a water-in-oil reverse microemulsion. Subsequent modification with (3-mercaptopropyl)trimethoxysilane and decoration with silver nanoclusters yielded Fe3O4@SiO2-Ag nanoparticles. Additionally, neat Fe3O4 particles were coated with Sipomer PAM-200 containing both phosphate and methacrylic groups, facilitating attachment to the iron oxide and enabling (co)polymerization with 2-(dimethylamino)ethyl methacrylate and/or 2- tert-butylaminoethyl methacrylate. Furthermore, γ-Fe2O3 nanoparticles were rendered antimicrobial through modification with...
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