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The release of terbinafine from polyesters branched with polyacrylic acid
Jakubíková, Hana ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Name of the student: Mgr. Hana Jakubíková Title of thesis: The release of terbinafine from polyesters branched with polyacrylic acid Consultant: PharmDr. Eva Šnejdrová, Ph.D. In this rigorous thesis, thermal and release properties of solid dispersions with terbinafine based on polyesters of lactic and glycol acid, branched with different concentration of polyacrylic acid, are studied and presented. Theoretical part summarizes current knowledge about terbinafine and its ways of application, advantages and disadvantages of solid dispersions and selection of a suitable polymeric carrier. In the experiment, solid dispersions were prepared by melting method, or solvent method using methyl-formate. The swelling rate and erosion rate were determined. The active pharmaceutical ingredient was incorporated into the polymer in form of hydrochloric salt or free base form in concentration of 10 %. Dissolution tests of terbinafine at 37 řC and pH 7.4 (phosphate buffer) were performed. Terbinafine concentration was determined spectrofotometrically at wavelength of 223 nm. Thermal analyses of solid dispersions revealed molecularly dispersed drug in concentration of 10 %. Polyesters degradation was running at pH 7,4 for...
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Biodegradable solid dispersion for application to mucous membranes
Janáková, Gabriela ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
1. ABSTRAKT CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Name of the student: Mgr. Gabriela Janáková Title of diploma thesis: Biodegradable solid dispersion for application to mucous membranes Consultant: PharmDr. Eva Šnejdrová, Ph.D. The aim of this work was to formulate solid dispersions for application to the mucosa and the skin in the form of a thin film and to study their dissolution properties. Solid dispersions were comprised of biodegradable copolymers of lactic acid and glycolic branched using 3% (3P) or 5% (5P) of pentaerythriol. They were prepared by a melting method with the addition of ethyl salicylate (ES) as a prodrug and plasticizer and optionally incorporating salicylic acid. As a dissolution medium phosphate buffer pH 7.4 was used. The theoretical part focuses on biodegradable polymers and solid dispersions. A faster course of salicylate release was observed in case of the polyester with higher molecular weight, higher branching ratio, and higher glass transition temperature. Higher content of ethyl salicylate slowed down salicylate release. After the incorporation of 5% salicylic acid into the polyester plasticized by ethyl salicylate, there was no expected elongation of salicylate release. The solid dispersion based on polyester...
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The release of terbinafine from polyesters branched with polyacrylic acid
Jakubíková, Hana ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Name of the student: Mgr. Hana Jakubíková Title of thesis: The release of terbinafine from polyesters branched with polyacrylic acid Consultant: PharmDr. Eva Šnejdrová, Ph.D. In this rigorous thesis, thermal and release properties of solid dispersions with terbinafine based on polyesters of lactic and glycol acid, branched with different concentration of polyacrylic acid, are studied and presented. Theoretical part summarizes current knowledge about terbinafine and its ways of application, advantages and disadvantages of solid dispersions and selection of a suitable polymeric carrier. In the experiment, solid dispersions were prepared by melting method, or solvent method using methyl-formate. The swelling rate and erosion rate were determined. The active pharmaceutical ingredient was incorporated into the polymer in form of hydrochloric salt or free base form in concentration of 10 %. Dissolution tests of terbinafine at 37 řC and pH 7.4 (phosphate buffer) were performed. Terbinafine concentration was determined spectrofotometrically at wavelength of 223 nm. Thermal analyses of solid dispersions revealed molecularly dispersed drug in concentration of 10 %. Polyesters degradation was running at pH 7,4 for...
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