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Design of LOKiA WMS web interface modifications
Záboj, Zdeněk ; Kříž, Jiří (referee) ; Neuwirth, Bernard (advisor)
This master thesis is focused on the design of web inteface modifications for LOKiA WMS provided by GRiT, s.r.o. that is a warehouse solution destined for companies of all sizes. The proposal of changes will be based on the analysis of the current state and its main goal is to achieve that the user interface is easier to use and more user friendly with acceptable financial costs.
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Database Design for Transport Company
Záboj, Zdeněk ; Luhan, Jan (referee) ; Kříž, Jiří (advisor)
The aim of this thesis is to design a database for an incipient transport company, for which the solutions available on the market nowadays don´t make sense due to its size. Within this thesis I am going to concentrate on designing the structure of the database and its implementation on Microsoft SQL Server platform using Microsoft Management Studio tools.
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Database Design for Small Animal Breeders
Záboj, Zdeněk ; Luhan, Jan (referee) ; Kříž, Jiří (advisor)
This master´s thesis is focused on the design of a database for small breeders, for whom it makes no sense to use large enterprise solutions. In this thesis I will focus on the analysis of the needs of those individuals and on the design of a database that will satisfy their needs with minimal financial requirements.
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Design of LOKiA WMS web interface modifications
Záboj, Zdeněk ; Kříž, Jiří (referee) ; Neuwirth, Bernard (advisor)
This master thesis is focused on the design of web inteface modifications for LOKiA WMS provided by GRiT, s.r.o. that is a warehouse solution destined for companies of all sizes. The proposal of changes will be based on the analysis of the current state and its main goal is to achieve that the user interface is easier to use and more user friendly with acceptable financial costs.
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Study of drug-drug interactions of antiviral drugs on intestinal transporters
Záboj, Zdeněk ; Červený, Lukáš (advisor) ; Vokřál, Ivan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Zdeněk Záboj Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Study of drugs interactions of antiviral drugs with intestinal transporters Sofosbuvir is an antiviral agent widely used in the treatment of chronic hepatitis C. This orally administered prodrug is a designed substrate of ATP-binding (ABC) efflux transporters, P- glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). ABCB1 and ABCG2 are important determinants of intestinal absorption and are the site of significant pharmacokinetic drug interactions, leading to changes in drug exposure. Pharmacokinetic drug interactions may be undesirable (increasing the toxicity of the treatment) or desirable (allowing dose reduction). Because sofosbuvir is often administered in combination regimens with other anti(retro)virotics, the aim of this thesis was to study the ability to enhance intestinal absorption of sofosbuvir. To study the pharmacokinetic drug interactions on ABCB1 and ABCG2, a widely established in vitro bi-directional transport method through a polarized monolayer formed by the Caco-2 cell line derived from colorectal cancer has been used. We analyzed the drug interactions of sofosbuvir on these efflux...
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Database Design for Small Animal Breeders
Záboj, Zdeněk ; Luhan, Jan (referee) ; Kříž, Jiří (advisor)
This master´s thesis is focused on the design of a database for small breeders, for whom it makes no sense to use large enterprise solutions. In this thesis I will focus on the analysis of the needs of those individuals and on the design of a database that will satisfy their needs with minimal financial requirements.
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Study of drug-drug interactions of antiviral drugs on intestinal transporters
Záboj, Zdeněk ; Červený, Lukáš (advisor) ; Vokřál, Ivan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Zdeněk Záboj Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Study of drugs interactions of antiviral drugs with intestinal transporters Sofosbuvir is an antiviral agent widely used in the treatment of chronic hepatitis C. This orally administered prodrug is a designed substrate of ATP-binding (ABC) efflux transporters, P- glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). ABCB1 and ABCG2 are important determinants of intestinal absorption and are the site of significant pharmacokinetic drug interactions, leading to changes in drug exposure. Pharmacokinetic drug interactions may be undesirable (increasing the toxicity of the treatment) or desirable (allowing dose reduction). Because sofosbuvir is often administered in combination regimens with other anti(retro)virotics, the aim of this thesis was to study the ability to enhance intestinal absorption of sofosbuvir. To study the pharmacokinetic drug interactions on ABCB1 and ABCG2, a widely established in vitro bi-directional transport method through a polarized monolayer formed by the Caco-2 cell line derived from colorectal cancer has been used. We analyzed the drug interactions of sofosbuvir on these efflux...
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Database Design for Transport Company
Záboj, Zdeněk ; Luhan, Jan (referee) ; Kříž, Jiří (advisor)
The aim of this thesis is to design a database for an incipient transport company, for which the solutions available on the market nowadays don´t make sense due to its size. Within this thesis I am going to concentrate on designing the structure of the database and its implementation on Microsoft SQL Server platform using Microsoft Management Studio tools.
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