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On Purinoceptors in the Rat Urinary Bladder
Veselá, Renata ; Wsól, Vladimír (advisor) ; Študent, Vladimír (referee) ; Broďák, Miloš (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate Mgr. Renata Veselá Supervisor Prof. Ing. Vladimír Wsól, Ph.D. Title of Doctoral Thesis On Purinoceptors in the Rat Urinary Bladder Both divisions of autonomic nervous system regulate the urinary bladder function. In addition to the classical autonomic neurotransmitters, noradrenaline and acetylcholine, other autonomic transmitters and signalling molecules play important roles in the physiology and pathophysiology of the lower urinary tract. Interstitial cystitis (IC) is a chronic inflammation of the bladder of non-infectious origin and unclear etiology and pathophysiology, characterized by urinary frequency, urgency and sharp pelvic pain that fade away while urinating. Non-adrenergic, non-cholinergic (NANC) systems influence functional responses in the inflamed bladder. The aim of this study was to investigate purinergic and nitrergic mechanisms involved in the IC pathogeneses and in urodynamic dysfunction. Methods: A single dose of i.p. injection of cyclophosphamide caused CYP-induced cystitis; a condition very similar to IC and for that property was used as a model of the inflamed bladder throughout our experiments. The organ bath set was employed in investigation of functional...
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On purinoceptors in the urinary bladder of hte rat: altered effects of purinergic P1A1 receptors in cystitis
Veselá, Renata ; Wsól, Vladimír (advisor) ; Soukup, Ondřej (referee)
This project was focused on studies of the location and function of selected purinergic receptors in the rat urinary bladder. Its special concerns are on adenosine P1A1 purinoceptors and on their expression in healthy and inflamed urinary bladders of the rat. It was found that both P2X1 and P1A1 receptors are expressed in urinary bladder. The quantity of P1A1 receptors is decreased in the inflamed bladder. Functional studies based on an agonist stimulation (adenosine) showed importance of P1A1 receptors for relaxation of the tissue. During the cystitis this effect was reduced. Electric field stimulation (EFS) pointed out the difference between the response to a stimulus affecting just postsynaptic receptors (adenosine stimulation) and responses to nerve stimulation including both post- and presynaptic effects.
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Úprava vykazování výnosů podle IFRS
Veselá, Renáta ; Hložková, Lenka (advisor) ; Vašek, Libor (referee)
Práce popisuje vykazování výnosů podle Mezinárodních standardů účetního výkaznictví. Rovněž vystihuje hlavní odlišnosti ve vykazování výnosů v České republice. Pro lepší pochopení dané problematiky zahrnuje řadu praktických příkladů. Práce uvádí také výzkum, který ukazuje, jak evropské společnosti dodržují pravidla pro vykazování výnosů stanovená Mezinárodními účetními standardy.
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