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Reinforced concrete tank
Vašinová, Martina ; Klusáček, Ladislav (referee) ; Strnad, Jiří (advisor)
Bachelor´s thesis deals with structural design and static assessment of reinforced concrete wastewater treatment plant. Specifically the calculation and assessment to the ultimate limit states (ULS) and seviceability limit states (SLS) of the foundation slab, perimeter wall, flume and his parts. On the basis of reports are prepared drawnings - reinforcement drawings and drawing shapes. The design was made on the values of the outputs of computer program Dlubal RFEM 6.0.1.
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Design of a prestressed footbridge
Vašinová, Martina ; Romportl, Tomáš (referee) ; Strnad, Jiří (advisor)
The subject of the master thesis is the design and assessment of a bridge structure across a deep valley in Blansko. At the beginning have been created three basic studies of the solved area. The bridge suported by concrete arch in plan curve was selected for closer assessment. Global calculation model was created in ANSYS Mechanical APDL 23 R1. Model of the slab of the deck in the cross direction was performer using DLUBAL RFEM 6.01. This thesis is extended with drawings of sequence of construction, detailed drawings of the bridge and visualizations.
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Development of diagnostic method in colorectal cancer
Pešková, Tereza ; Fikrová, Petra (advisor) ; Vašinová, Martina (referee)
The bachelor thesis is a review focused on colorectal cancer (CRC), its incidence, prevention, treatment, but especially on the methods of diagnosis that help to detect this disease. In the first part of the thesis, the colon is anatomically and histologically described. Next is presented the disease of the CRC, its origin, occurrence, symptoms, prevention, and finally treatment options. In the next part, the work focuses on specific methods of diagnosis. One of the most effective method for early detection of cancer is a screening program that uses the methods of examination of occult bleeding into the stool and colonoscopy. Colonoscopy itself is considered to be the gold standard for the diagnosis of CRC. Despite the development of new and more modern methods for diagnosis, colonoscopy is still one of the most widely used and most reliable methods. Furthermore, radiological methods, especially computed tomography (CT) or magnetic resonance imaging (MRI), are described. These methods have made a great move towards detecting lesions more accurately and earlier. These methods are also still often combined with colonoscopy to provide a more comprehensive and detailed picture for diagnosis. These new methods, such as virtual colonoscopy, positron emission tomography combined with CT (PET/CT), or...
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Reinforced concrete tank
Vašinová, Martina ; Klusáček, Ladislav (referee) ; Strnad, Jiří (advisor)
Bachelor´s thesis deals with structural design and static assessment of reinforced concrete wastewater treatment plant. Specifically the calculation and assessment to the ultimate limit states (ULS) and seviceability limit states (SLS) of the foundation slab, perimeter wall, flume and his parts. On the basis of reports are prepared drawnings - reinforcement drawings and drawing shapes. The design was made on the values of the outputs of computer program Dlubal RFEM 6.0.1.
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Immunohistochemical analysis of endoglin and cell adhesion molecules expression in NASH experimental model
Vašinová, Martina ; Nachtigal, Petr (advisor) ; Němečková, Ivana (referee)
Nonalcoholic steatohepatitis (NASH) is an aggressive form of nonalcoholic fatty liver disease, which is characterized by liver inflammation and fibrosis. It was shown that membrane endoglin (ENG) participates on fibrosis and plasma concentrations of soluble endoglin were increased in patients with type II diabetes mellitus, and hypercholesterolemia. The purpose of this study was to analyze the expression of ENG, biomarker of fibrosis (αSMA/alpha smooth muscle actin), and biomarkers of inflammation (ICAM-1, VCAM-1) in liver in mice. Wild type mice were divided into two groups (n=8 in each group), control group was fed with chow diet and experimental/NASH group was fed with high fat diet with fructose and glucose in drinking water (NASH diet) for 6 months. Expression of selected proteins was evaluated by means of immunohistochemistry (ImmPRESSTM and VECTASTAIN® ELITE® ABC kit) on formalin-fixed, paraffin-embedded liver sections. The results of this study showed that the expression of VCAM-1 and ICAM-1 was detected in liver sinusoids and it was higher in NASH group. Similarly, we showed higher expression of ENG in NASH group in comparison with control. Moreover, αSMA was found not only in blood vessels, but also in hepatic stellate cells in NASH group compared to control suggesting fibrotic process...
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Daunorubicin effects on atherogenesis in rabbits fed by cholesterol diet.
Vašinová, Martina ; Nachtigal, Petr (advisor) ; Němečková, Ivana (referee)
Daunorubicin (DAU) was the first anthracycline (ANT) antibiotic with impressive clinical activity in the treatment of acute pediatric leukemias. Later, it has been shown that anthracyclines have broad range of therapeutic activities against both hematological and solid tumors, including breast, ovarian and gastric carcinoma. On the other hand, ANTs are the most dangerous anticancer drugs with respect to cardiovascular toxicity characterized by mostly irreversible morphological changes and cell death. Indeed, ANTs are used also in patients with hypercholesterolemia so the effect on atherogenesis in blood vessels is of interest. Thus, we hypothesized that DAU treatment and cholesterol diet will aggravate atherosclerosis when compared to rabbits fed by cholesterol diet only. Twelve adult male New Zealand White rabbits were fed with cholesterol diet (0.2% cholesterol). Control group of rabbits (n=7) received saline i.v. once weekly for 10 weeks since the beginning of the 4th week, the second DAU group (n=7) received clinically relevant doses of daunorubicin (3 mg/kg, ≈ 50 mg/m2, i.v.). The systematic uniform random sampling was applied for the quantification of atherosclerotic lesions. The samples from aortic arch were taken for the evaluation. Serial sections of vessel (7 μm) were cut on a cryostat...
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