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Stability testing of thiomersal stock solution by HPLC
 Unverdorbenová, Veronika ; Matysová, Ludmila (advisor) ; Sklenářová, Hana (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Veronika Unverdorbenová Supervisor: doc. PharmDr. Ludmila Matysová, Ph.D. Title of the diploma thesis: Testing the stability of spare thiomersal solution by HPLC method. The aim of this thesis is testing the stability of thiomersal and subsequently establish conditions of storing the thiomersal solution. Reversed-Phase High Performance Liquid Chromatography was used for observing the concentrations of thiomersal in samples kept in different conditions. Tested samples were aqueous solutions of thiomersal with pH 6,85 and 7,5. These samples were stored in dark glass and plastic containers. Due to the non- photostability of thiomersal, the samples were stored in the dark. The temperature was laboratory and 4 řC. The samples were observed for the period of 90 days. Following the analysis, the most convenient conditions for storing the thiomersal solution is lowered temperature around 4 řC a pH 7,5. Under these storage conditions there were no substantial differences in the stability of thiomersal in the samples stored in plastic or glass containers. These samples were stable for the period of three months.
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