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Financial supervision in the EU - comparison of the CR and Great Britain
Loub, David ; Sedláková, Lenka (referee) ; Kopřiva, Jan (advisor)
On the first April 2006 came to the turning point in the Czech Republic in the sphere of supervision and regulation over financial market, whereby approach more ideal European markets. In the master's thesis I focus on the present state of supervision and regulation of the financial market in CR, but also on system development before the 1. April 2006. I also deal with operating system on the financial market in Great Britain. The aim of my thesis is comparison of supervision and regulation in the Czech Republic and Great Britain.
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Pathophysiological mechanisms of chronic kidney disease progression
Sedláková, Lenka ; Kopkan, Libor (advisor) ; Švandová, Ivana (referee)
The kidneys are an essential organ that maintains the homeostasis of body fluid and ions, it filters metabolites and plays important endocrine role. Renal function is controled by many mechanisms with a close interaction that can work independently without central control. These mechanisms are regulated by both systemic and intrarenal humoral systems and their physiological balance sustains the optimal kidney fuction. Any disturbance of this balance leads to the impairments of renal function and progression of renal injury and thus the kidney works inappropriately. The renal insufficiency and diseases remain significant problem despite modern medicine. This is results of several risk factors such as age, genetic predisposition and low birth weight, increase of civilization diseases - diabetes, hypertension, autoimmune disorders, but also bad habits such as unhealthy lifestyle, smoking etc. These factors can lead to the acute or chronic kidney diseases often without known cause. Than the question is an early diagnosis and optimal treatment to preserve kidney function and stop the progression of terminal renal damage. This thesis should show the importance of kidney function and outline problems and consequences of renal insufficiency particularly during chronic kidney disease. Keywords: Renal...
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Onemocnění pohybového aparátu u hříbat a mladých koní
Sedláková, Lenka
The thesis deals with diseases of muskuloskeletal systém of foals and young horses, concretly then osteochondrosis, flexural and angular deformities, tendon laxity and physitis. The method is based on case studies and evaluation questionnaire among horse breeders. On the basis of these data was determined preventive recommendations to farmers. Given that all these diseases are multifactorial in nature and their etiology is similar, are named as developmental orthopedic disease. The main causes are genetics, nutrition, exercise management and growth rate of the individuals who are directly related to the causes mentioned. Clinical symptoms vary widely depending on severity. Likewise therapy often is not needed, but may occur also to cases which are very important to today's intractable methods. The aim is to provide recommendations to farmers how to recognize the severity of the disease and how to avoid them.
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Effect of combined endothelin and renin-angiotensin systems blockade on blood pressure and chronic kidney disease regression in model of angiotensin II-dependent hypertension
Sedláková, Lenka ; Kopkan, Libor (advisor) ; Bürgelová, Marcela (referee)
and key words Enhanced activation of renin-angiotensin system (RAS) and endothelin system (ES) plays the key pathophysiological role in the progression of hypertension and the chronic kidney disease (CKD). The aim of this study was to verify wheter the combined inhibition RAS and selective inhibition ETA receptor for endothelin 1 (ET-1) will show additive renoprotective effects in experimental model CKD. This therapeutic aproach was tested on the transgenic rats with mouse renin gen (TGR), to whome ablation nephrectomy (5/6 NX) was done in the age of 6 weeks. After next 6 weeks the relevant treatment was given in drinking-water: dual RAS blockade (trandolapril 6mg/L + losartan 100mg/L) or the combination of dual RAS blockade + inhibitor of ETA receptor (atrasentan 25mg/L). Results of the first series show 100 % mortality in untreated rats with 5/6 NX to the 30th week. Both type of treatments increased the survival rate up to 30 % in 5/6 NX TGR after the 50th week. In the second series influence of treatments on the blood pressure (BP) was monitored in 5/6 NX TGR, which had systolic BP over 210 mmHg. Both treatments decreased BP to the level normotensive rats and reduced heart hypertrophy. In the third series the results showed that treatment significantly decreased renal level of angiotensin II...
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Pathophysiological mechanisms of chronic kidney disease progression
Sedláková, Lenka ; Kopkan, Libor (advisor) ; Švandová, Ivana (referee)
The kidneys are an essential organ that maintains the homeostasis of body fluid and ions, it filters metabolites and plays important endocrine role. Renal function is controled by many mechanisms with a close interaction that can work independently without central control. These mechanisms are regulated by both systemic and intrarenal humoral systems and their physiological balance sustains the optimal kidney fuction. Any disturbance of this balance leads to the impairments of renal function and progression of renal injury and thus the kidney works inappropriately. The renal insufficiency and diseases remain significant problem despite modern medicine. This is results of several risk factors such as age, genetic predisposition and low birth weight, increase of civilization diseases - diabetes, hypertension, autoimmune disorders, but also bad habits such as unhealthy lifestyle, smoking etc. These factors can lead to the acute or chronic kidney diseases often without known cause. Than the question is an early diagnosis and optimal treatment to preserve kidney function and stop the progression of terminal renal damage. This thesis should show the importance of kidney function and outline problems and consequences of renal insufficiency particularly during chronic kidney disease. Keywords: Renal...
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Financial supervision in the EU - comparison of the CR and Great Britain
Loub, David ; Sedláková, Lenka (referee) ; Kopřiva, Jan (advisor)
On the first April 2006 came to the turning point in the Czech Republic in the sphere of supervision and regulation over financial market, whereby approach more ideal European markets. In the master's thesis I focus on the present state of supervision and regulation of the financial market in CR, but also on system development before the 1. April 2006. I also deal with operating system on the financial market in Great Britain. The aim of my thesis is comparison of supervision and regulation in the Czech Republic and Great Britain.
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Výcvik Irského setra pro mysliveckou praxi
Sedláková, Lenka
In bachelor's work are described the most important parts of training Irish Setter aim to use for hunting. The training is divided according to hunting examinations, which can the owners with their dogs participate in. Temperament and exterior of the breed, history of breeding and hunting with setters and the conditions for breeding in Czech Republic are cha-rakterized. Also are coverd with writing my own experiences with training irish setter.
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