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Inovation in influenza vaccines
Satoriová, Martina ; Drda Morávková, Alena (advisor) ; Motlová, Lucia (referee)
Influenza viruses annually infect 3 to 5 millions of people worldwide, cause annually many hospitalizations, 250 000-500 000 deaths and significant economical losses. The vaccines still remain the most efficient way of prevention of this infectious disease. Conventional egg- based vaccines are used for more than 60 years. Although they are safe, they have many disadvantages. Their main disadvantage is the relatively low effectiveness and time-limited induced immunity. The need for annually updates of their composition due to an antigenic variability of viral surface proteins can be considered a disadvantage as well. What is more, the dependence on an egg suply and a way too long time of preparation might be limiting in the case of pandemic. The development of an universal vaccine that would induce a broad imunne response against different strains of Influenza and longlasting protection is a worldwide priority.
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Inovation in influenza vaccines
Satoriová, Martina ; Drda Morávková, Alena (advisor) ; Motlová, Lucia (referee)
Influenza viruses annually infect 3 to 5 millions of people worldwide, cause annually many hospitalizations, 250 000-500 000 deaths and significant economical losses. The vaccines still remain the most efficient way of prevention of this infectious disease. Conventional egg- based vaccines are used for more than 60 years. Although they are safe, they have many disadvantages. Their main disadvantage is the relatively low effectiveness and time-limited induced immunity. The need for annually updates of their composition due to an antigenic variability of viral surface proteins can be considered a disadvantage as well. What is more, the dependence on an egg suply and a way too long time of preparation might be limiting in the case of pandemic. The development of an universal vaccine that would induce a broad imunne response against different strains of Influenza and longlasting protection is a worldwide priority.
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Fish Rhabdoviruses and its prevention
Satoriová, Martina ; Drda Morávková, Alena (advisor) ; Novák, Josef (referee)
The rise of aquaculture has been one of the most significant changes in global food production over the last 100 years. Driven by rising demand for seafood, the growth of population, the farming of aquatic animals has expanded rapidly to become a major global industry. A number of aquatic animal species is kept in high densities in freshwater, brackish and marine systems where they are exposed to a new environment and potentially new diseases. On-farm stresses may negatively affect their ability to defeat infection. Impefect farming practices often facilitate fast transmission of disease. Viral pathogens, whether they have been known for decades or whether they are newly emerging, are particularly challenging since there are few, if any, efficacious treatments. The development of effective viral vaccines for delivery in aquatic systems still remains almost elusive. This thesis reviews a few of the more significant Rhabdoviral pathogens of finfish, their impacts, their prevention and the protective immune mechanisms that fish mount in response to rhabdovirus infections.
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