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Synthesis of new guaiazulene derivatives
Počtová, Žofie ; Kotora, Martin (advisor) ; Smrček, Stanislav (referee)
Synthesis of new guaiazulene derivates (abstract) This bachelor thesis concerns preparation of new guaiazulene derivates. The purpose of this work was to try some already known reactions and some new ones. Acylation of guaiazulene was carried out and was followed by oxidation, decarboxylation, allylation, and Diels-Alder reaction of the prepared guaiazulene derivates. The desired products were obtained in acylation, oxidation, and allylation reactions. Characterization of the prepared substances was performed by using NMR, IR or MS techniques.
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Study of vortioxetin complexation by native cyclodextrins and its determination using capillary electrophoresis
Počtová, Žofie ; Křížek, Tomáš (advisor) ; Sobotníková, Jana (referee)
In this master thesis, the formation of supramolecular complexes between vortioxetine active substance and cyclodextrins (α, β, γ) is examined and the stability constants of these complexes are determined. The stoichiometric ratios of cyclodextrin and vortioxetine 1:1 and 2:1 are considered. The results suggest that the 1:1 ratio of cyclodextrin and vortioxetine is more accurate for each of used cyclodextrins and that the strongest interaction is between vortioxetine and β-cyclodextrin. Further, a method for vortioxetine assay in a tablet is developed by using non-aqueous capillary electrophoresis technique. The precision, accuracy, and robustness are validated and the values of detection and quantification limits are determined. This method can be used as a verification method for the results obtained by HPLC as the separation principle is different in capillary electrophoresis. Also, the stability of vortioxetine as a pure powder and as a mixture with excipients is examined under the conditions of elevated temperature and humidity.
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Synthesis of new guaiazulene derivatives
Počtová, Žofie ; Kotora, Martin (advisor) ; Smrček, Stanislav (referee)
Synthesis of new guaiazulene derivates (abstract) This bachelor thesis concerns preparation of new guaiazulene derivates. The purpose of this work was to try some already known reactions and some new ones. Acylation of guaiazulene was carried out and was followed by oxidation, decarboxylation, allylation, and Diels-Alder reaction of the prepared guaiazulene derivates. The desired products were obtained in acylation, oxidation, and allylation reactions. Characterization of the prepared substances was performed by using NMR, IR or MS techniques.
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