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National Repository of Grey Literature

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Ethics in social services: Involvement of peer consultants in social services for people with mental illness Balková, Miluše ; Holmerová, Iva (advisor) ; Hradcová, Dana (referee) ; Páv, Marek (referee) Involvement of people with experience of disease as a peer consultant in social and health services is a new phenomenon in the care of people with mental illness. The way the peer consultant works and his involvement in the team of experts is related to the different ethical contexts and aspects that each organization must prepare if it wants to implement this position. The experience of peer consultants is also a testimony of the status of people with mental illness in society, stigmatization and the need to help people in a similar situation. Klíčová slova illness, mental, care, psychiatric, altruism, solidarity, society, belonging, ethics, services, social, health, helping, sharing Detailed record

Assesment of stress and psychotropic induced changes of trimetric G protein subunit levels and cellular functions in vitro and in vivo in the context of depressive disorder Páv, Marek ; Kovářů, Hana (advisor) ; Höschl, Cyril (referee) ; Doležal, Vladimír (referee) Depression is a complex systemic disorder with exhibiting biological, cognitive and psychopathological symptoms. There are changes in hormonal regulation, immune changes and disturbance in function of especially monoamine and indoleamine neurotransmitter circuits in the CNS. Pharmacologic intervention with antidepressants is treating depressive syndrome as well as homeostatic imbalance. These neurotransmitter systems use in the signal transduction from membrane into the cell receptors coupled with heterotrimeric G proteins (GTP binding proteins).This thesis studies changes in G protein subunit levels induced by stress and psychotropic drugs in the CNS and immune system of experimental mice and antidepressant induced changes in vitro in the C6 glioma cell line an in vivo in the rat tissue. Immobilization stress induces prominent changes in the G protein subunit levels in the spleen and CNS of experimental mice with analogical profile of response. Results show importance of stress dopaminergic component in the leukocyte function regulation and also demonstrate importance of dopaminergic regulation without stress exposition. Findings obtained in the glioma C6 cell line show antidepressant induced drug specific changes of the G subunit profiles and demonstrate thus mode of action independent on the... Detailed record

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1	Páv, Martin

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