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Testing of binders of thermal insulations for specific applications on technical appliances
Maňák, Jan ; Kulísek, Karel (referee) ; Petránek, Vít (advisor)
This work focus on testing alcali-activated binders for thermal insulation which could be used for special industry devices. In the beginning of this work is presented example of thermal energy storage where these specific alcali-activated materials can be used. Ensuingly two construction with thermal energy storage tanks are mentioned. Most of the interest aims on ageing and rheological properties of alcali-activated binder. Some rheological methods are also discussed. In the end of this work is added practical experience.
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Mineralizers Using in the Silica Materials Production Process
Maňák, Jan ; Sokolář, Radomír (referee) ; Nevřivová, Lenka (advisor)
Silica bricks is a refractory material whitch is used mainly in glass furnaces, coke oven bateries and hot blast stoves. Silica bricks constitute of the crystalline phases cristobalite, tridymite, glass phase and unconverted quartz. Content of these phases influences eventual properteis of silica bricks. This thesis deals with influence of the different kind of mineralizers, method of homogenization and length of firing on the content of these phases and eventual properties of silica bricks.
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Optimization of Working Mass Composition for Dense Silica Bricks Production.
Maňák, Jan ; Lang,, Karel (referee) ; Nevřivová, Lenka (advisor)
A silica bricks is a refractory material which is used mainly in coke industry, glass industry and metallurgy. This material constitute of the quartz modifications. Compact silica is an irreplaceable part of the coke battery and its compactness and robustness is important for quality and long endurance. Very important for large compactness is a grain curve of work matter. This thesis deals with influence of different grain of work matter.
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Acute kidney injury in sepsis: phatophysiological and therapeutical aspects
Chvojka, Jiří ; Matějovič, Martin (advisor) ; Kasal, Eduard (referee) ; Maňák, Jan (referee) ; Balík, Martin (referee)
Sepsis and septic shock remain major cause of mortality in non-coronary intenisve care units. Prognosis of septic patiens worsens further in case of concomitant acute kidney injury. Pathophysiological pathways leading to renal dysfunction in sepsis remain unclear despite of enormous experimental and clinical research. Similarly, the role of extracorporeal blood purification techniques as an adjunctive treatment in sepsis is highly controversial. The aim of our study was to dynamically assess renal haemodynamic, microvascular and metabolic responses in a porcine clinically relevant model of septic shock. The same experimental model was used in experiments elucidating potential benefit effects of two distinct haemopurification methods on different biological responses to infectious insult.
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The influence of early intensified rehabilitation on the clinical outcome of critically ill patients
Waldauf, Petr ; Duška, František (advisor) ; Hagovská, Magdaléna (referee) ; Maňák, Jan (referee)
1 Executive Summary The overarching goal of this thesis was to assess the efficacy and safety of an innovative rehabilitation technique - functional electrical stimulation-assisted cycle ergometry - in critically ill patients. We firstly (Project A) investigated physiological changes induced by this technique in a group of 14 healthy volunteers and compared it, in a cross-over design, to normal volitional low intensity exercise. We have shown an increase in whole-body energy expenditure similar to 25 W exercise. Then (Project B) we have performed a meta-analysis of randomised-controlled studies available to date to compare in the population of critically ill patients the effect of neuromuscular electrical stimulation, passive cycling, and early goal-directed rehabilitation. We found that only goal directed rehabilitation has positive effects on patient-centred outcomes. There were no published studies using functional electrical stimulation-assisted cycle ergometry. Lastly (Project C) in a large, single centre randomised controlled trial we have tested an innovative functional electrical stimulation-assisted cycle ergometry-based early rehabilitation protocol compared to standard of care in critically ill patient. We have not found any significant differences in the physical function after six months of...
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The Intensive Care Unit-Acquired Weakness: the role of mitochondrial dysfunction in its pathogenesis
Jiroutková, Kateřina ; Duška, František (advisor) ; Houštěk, Josef (referee) ; Maňák, Jan (referee)
BACKGROUND: ICU-acquired weakness impairs functional outcome in survivors of critical illness. Therefore, deepening our understanding of its pathogenesis is an important goal as muscle-specific therapeutic targets are urgently needed. Systemic inflammation and sepsis are the main risk factors of ICUAW, and these syndromes are associated with mitochondrial dysfunction. The aim of our study was to collect reliable information on the mitochondrial function of human skeletal muscle in the protracted phase of critical illness. Additionally, we explored mitochondrial respiratory parameters following experimentally induced changes in the availability or composition of selected nutrients (fatty acids and glutamine). MATERIALS and METHODS: Vastus lateralis muscle biopsy samples from patients with ICU- acquired weakness and age-matched healthy controls were obtained. In human skeletal muscle tissue homogenates mitochondrial functional indices were assessed by high- resolution respirometry, individual functional capacities of respiratory complexes were measured by spectrophotometry and correlated with concentrations of electron transport chain key subunits measured by western blot. Additionally, using human myoblasts and myotubes we studied the influence of extracellular environment manipulations by...
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