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Theme of Guilt and Punishment in Stories and Dramatic of František Langr in Domestic and Global Context
Krsková, Kateřina ; Mravcová, Marie (advisor) ; Holý, Jiří (referee)
The thesis describes the evolution and variances in the motive of crime and punishment throughout prosaic and dramatic works of František Langer. After an introductory reflection on crime and punishment the thesis deals with an analysis of Doskojevskij's novel "Crime and Punishment" which had a large impact on Langer's conception of these terms. It also outlines an image of crime and punishment in Czech literature at the turn of the 19th and 20th century, which might have influenced Langer. The first part also tries to clarify how these motives were evolved in author's incipient work. It follows up prose collections "Gold Venus" and "Dreamers and Murderers". The second part is focused on the refined and often very complicated form of crime and punishment in Langer's dramas "Saint Wenceslas", "Periphery", "Camel through Eye of a Needle", "Reversal of Ferdyš Pištora", "Angels among us" and "Seventy-two" and tries to grasp and characterize it.
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Theme of Guilt and Punishment in Stories and Dramatic of František Langr in Domestic and Global Context
Krsková, Kateřina ; Mravcová, Marie (advisor) ; Holý, Jiří (referee)
The thesis describes the evolution and variances in the motive of crime and punishment throughout prosaic and dramatic works of František Langer. After an introductory reflection on crime and punishment the thesis deals with an analysis of Doskojevskij's novel "Crime and Punishment" which had a large impact on Langer's conception of these terms. It also outlines an image of crime and punishment in Czech literature at the turn of the 19th and 20th century, which might have influenced Langer. The first part also tries to clarify how these motives were evolved in author's incipient work. It follows up prose collections "Gold Venus" and "Dreamers and Murderers". The second part is focused on the refined and often very complicated form of crime and punishment in Langer's dramas "Saint Wenceslas", "Periphery", "Camel through Eye of a Needle", "Reversal of Ferdyš Pištora", "Angels among us" and "Seventy-two" and tries to grasp and characterize it.
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The metabolism of an adipose tissue in mice with high-fat diet-induced obesity: the role of anatomical localization of the tissue and diet composition
Krsková, Kateřina ; Janovská, Petra (advisor) ; Behuliak, Michal (referee)
Regulation of the flow of fatty acids (FA) by futile cycle (TAG/FA cycle) in white adipose tissue (WAT) is an important mechanism of controlling metabolism of FA and therefore its regulation is in the interest of research as a possible therapeutic target in the treatment of obesity and insulin resistance. The study of the murine model suggests that the treatment of the n-3 PUFA with mild caloric restriction (CR) probably induces the TAG/FA cycle mainly in epididymal depot. It also reduces inflammation in WAT and the risk of cardiovascular diseases. We focused on monitoring the gene expression encoding key enzymes of the TAG/FA cycle (PEPCK, ATGL, HSL, DGAT1 and DGAT2) in dorzolumbar (DL), gonadal (GON) and mesenteric (MEZ) depot in a murine model C57BL/6 using qPCR. We were interested in the influence of the composition of fats in the diet, the influence of administration of n-3 PUFA with combination of 10% CR and the difference of gene expression among depots of WAT. The results indicate that the supplementation of high-fat diet with n-3 PUFA contributes mainly to reduction of gene expression for DGAT2 and the combination of n-3 PUFA and CR increases expression of genes influencing the TAG/FA cycle. In MEZ unlike GON and DL fat depot were no significant differences in gene expression, while the different...
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Refeeding syndrome
Krsková, Kateřina ; Novák, František (advisor) ; Křížová, Jarmila (referee)
Refeeding syndrome (RFS) is a serious metabolic disorder caused by improper procedure of realimentation in patients, who are starved or severely malnourished. All clinical features of the syndrome are result of many metabolic changes, which are mainly caused by depletion of phosphate, potassium, magnesium and thiamine, as well as retention of sodium and disturbed glucose metabolism. The theoretical part of this thesis summarizes the current knowledge about the prevention of the RFS. The research part of the thesis explores the influence of intense realimentation in high-risk patients, particularly the values of various biochemical parameters before or during the early beginning of the realimentation. We measured values of indirect calorimetry, BMI, serum concentrations of phosphate, potassium, magnesium, prealbumin, albumin, zinc, iron and vitamin D. We also monitored concentrations of phosphorus, potassium, magnesium and cortisol in urine. We reported reduced values of potassium in urine for all patients (5/5) and reduced values of phosphate in urine for four patients (4/5). In four patients (4/5) we also monitored decreased levels of serum prealbumin, including two patients even below the value of 0.1 g/l, which is considered to be a significant risk factor for the development of the RFS. We...
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