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Beta-lactam Antibiotics Level Monitoring in Febrile Neutropenia Patients and Patients with Sepsis
Zavřelová, Alžběta ; Žák, Pavel (advisor) ; Válková, Veronika (referee) ; Krejčí, Marta (referee)
Beta - lactam antibiotics level monitoring in febrile neutropenia patients and patients with sepsis. Monitoring of antibiotic blood concentration in hemato-oncological patients was primary objective of this work. Monitoring of antibiotics level were done mainly in antibiotics used for gram-negative infections treatment (piperacilline, meropenem, ceftazidime) or for the treatment of febrile immunocompromised patient, usually neutropenic. For individual pharmacokinetics evaluation blood concentration were taken during the administration of prolonged antibiotics infusion. It was further used to create population model. Monte Carlo simulation was then used for creation of final model and for demonstration of pharmacokinetics/pharmacodynamics goals. Pharmacokinetics/pharmacodynamics goals were primary aim of whole study for different antibiotics during the use in stable hemato-oncological patients but also critical patients. Clinical data were used for further study, where we proved high clinical efficacy of high dose ceftazidime in the treatment of extended drug resistant Pseudomonas aeruginosa infection in hemato-oncological patients.
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Multiple myeloma- diagnosis and treatment
Jungová, Alexandra ; Vokurka, Samuel (advisor) ; Krejčí, Marta (referee) ; Minařík, Jiří (referee)
Multiple myeloma is an agressive hemato-oncological disease the diagnosis and treatment possibilities of which have been developing for the last 15 years. The diagnostic methods include flow cytometry which uses antigen detection to distinguish between pathological and physiological plasmocytes. One of the monitored markers is marker CD45 which could be, according to our monitoring, of a negative prognostic value. 71 patients in our group were divided according to the intensity of CD45 antigen expression and the group with a lower expression showed a statistically higher risk of relapse within 12 months 62% vs. 25 % (p=0,0011). We did not find any connection with the influences of induction therapy or cytogenetics which are otherwise considered the most important prognostic markers. Multiple myeloma treatment involves a lot of combined protocols; and the repeated autologous transplantation is still considered to be the most efficient. We observed more positive results in planning the second autologous transplant early in patients who reached just partial remission after the 1st autologous transplant - significantly better TFS (treatment free survival) and overall survival (OS) were in the group of patients with early tandem transplantation: 18 months vs. 10 months (p=0.04) and the OS median was not reached...
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Multiple myeloma- diagnosis and treatment
Jungová, Alexandra ; Vokurka, Samuel (advisor) ; Krejčí, Marta (referee) ; Minařík, Jiří (referee)
Multiple myeloma is an agressive hemato-oncological disease the diagnosis and treatment possibilities of which have been developing for the last 15 years. The diagnostic methods include flow cytometry which uses antigen detection to distinguish between pathological and physiological plasmocytes. One of the monitored markers is marker CD45 which could be, according to our monitoring, of a negative prognostic value. 71 patients in our group were divided according to the intensity of CD45 antigen expression and the group with a lower expression showed a statistically higher risk of relapse within 12 months 62% vs. 25 % (p=0,0011). We did not find any connection with the influences of induction therapy or cytogenetics which are otherwise considered the most important prognostic markers. Multiple myeloma treatment involves a lot of combined protocols; and the repeated autologous transplantation is still considered to be the most efficient. We observed more positive results in planning the second autologous transplant early in patients who reached just partial remission after the 1st autologous transplant - significantly better TFS (treatment free survival) and overall survival (OS) were in the group of patients with early tandem transplantation: 18 months vs. 10 months (p=0.04) and the OS median was not reached...
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Progress of municipality revenues in Czech republic
KREJČÍ, Marta
The thesis is focused on the progress of municipality revenues of municipality. There are several posible dependencys on: government sector and on tax revenues. Tax revenues are depend on the law of budgetary distribution of taxes. Tax buoyancy is calculated only for several chosen that are important for municipality budget. There are also considered irrecoverably revenues, wchich adjust the distribution of grands. It dependence on grown province of municipality. Thesis researches period of time between 19982012. Revenues volatility might be caused by amendment (retirement laws or budgetary distribution of taxes) and by economic cycle. Almoust all from kinds of revenues showed more dependency on economic cycle than on changes of government laws. The only exeption is property tax which grew even in time of economic crises becouse of amendment of law 2009.
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Budget municipal towv Trhové Sviny
KREJČÍ, Marta
The thesis is focused on the law amendment regarding vat (value added tax) effective from 1.4.2011. The municipal town Trhové Sviny was used for the analysis. The thesis is divided into two parts ? theoretical and practical. Horizontal and vertical analysis are used for breakdown. The influence of law amendment is showed by practical examples. Finally, there is an evaluation of the law change impact on to the municipal town...as a result, the amendment did not prove influence in 2011 and it also shows changes that could have positive influence on the municipal budget.
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