|
|
Study of plasma protein binding of receptor-specific peptides
Křivková, Šárka ; Lázníček, Milan (advisor) ; Trejtnar, František (referee)
SUMMARY: Drug binding to plasma proteins is one of the primary pharmacological parameters. The binding rate has significant effects on drug distribution and drug elimination. In vitro investigation of plasma protein binding helps us foresee their destiny after its administration to a living organism. This dissertation focused on studying plasma protein binding of DOTA-NOC marking by 90 Y and 111 In in term of interspecies comparison. The binding was determined by methods of equilibrium dialysis at 37řC. Results showed binding of 90 Y-DOTA-NOC increases respectively: human < rabbit < bovine < rat plasm. Binding of 111 In-DOTA-NOC increases respectively: pork < human < rat < rabbit plasm. KEYWORDS: protein binding, DOTA-NOC, 111 In, 90 Y, interspecies comparison
|
|
|
Contraception among secondary school and university students
KŘIVKOVÁ, Šárka
The thesis on "Contraception in High School and among College Youth" is focused on the mapping of knowledge about the possibilities and methods of contraception. The theoretical part of this bachelor thesis characterizes and defines the concept of contraception and describes its methods and types. It also includes a history of contraception, the sexuality of youth, and the characteristics of development during adolescence. Because it is important not only to teen girls to be thoroughly informed about the possibilities of contraception, the last chapter also mentions the role of the midwife in educating girls about contraception. A methodology of quantitative research was chosen for this thesis and the technique of a questionnaire and a poll was chosen for data collection. The data obtained was further processed and evaluated using the Microsoft Excel computer program and was subsequently evaluated using PivotTables. The so-called Pearson chi-square goodness-of-fit test was used to statistically test the hypotheses. In addition, charts have been drawn up for individual questions from the questionnaire and poll, which illustrate respondents' answers. The research group for the research investigations were girls and young women from secondary schools and universities of the South Bohemian Region aged from 16 to 26 years. Questionnaires were sent electronically. In total, 555 questionnaires were obtained, of which 440 were used for research. The aim of this study was to map the knowledge of girls and young women in selected secondary schools and universities about the methods of contraception. Three hypotheses have been established. The first hypothesis was to find out if there are differences in knowledge about methods of contraception among students of health and secondary schools and students of other secondary and higher education institutions. This hypothesis has not been confirmed, because there was no difference in knowledge about contraceptive methods between the selected groups. The second hypothesis was used to find out whether university students have a better understanding of contraceptive methods than secondary school students. This hypothesis has been confirmed, for college students have a better understanding of contraceptive methods than high school students. The third hypothesis assumes that college students prefer hormonal contraceptives more than high school students, which has not been confirmed, as according to tables and statistical tests we have found that there were no statistical differences in preference for hormonal contraceptives amongst secondary and university students. From the results of the questionnaire survey it is clear that college students generally have a better knowledge of contraception than high school students, regardless of whether it is a health-related school. It turned out that girls at a younger age tend to choose a hormonal contraceptive method and are not aware of other methods. This work could be used as an educational or informational material for students of secondary schools and universities. An information leaflet, which is the output of this thesis, can serve as information material for high school and university youth.
|
|
|
Study of plasma protein binding of receptor-specific peptides
Křivková, Šárka ; Lázníček, Milan (advisor) ; Trejtnar, František (referee)
SUMMARY: Drug binding to plasma proteins is one of the primary pharmacological parameters. The binding rate has significant effects on drug distribution and drug elimination. In vitro investigation of plasma protein binding helps us foresee their destiny after its administration to a living organism. This dissertation focused on studying plasma protein binding of DOTA-NOC marking by 90 Y and 111 In in term of interspecies comparison. The binding was determined by methods of equilibrium dialysis at 37řC. Results showed binding of 90 Y-DOTA-NOC increases respectively: human < rabbit < bovine < rat plasm. Binding of 111 In-DOTA-NOC increases respectively: pork < human < rat < rabbit plasm. KEYWORDS: protein binding, DOTA-NOC, 111 In, 90 Y, interspecies comparison
|
guest ::
