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Steroid metabolome and multiple pregnancy
Černý, Andrej ; Pařízek, Antonín (advisor) ; Hubka, Petr (referee) ; Kiss, Imrich (referee)
Steroid hormones can be divided into 2 groups - intracellular and extracellular, depending on location of their activity. Intracellular ones influence expression of genes while acting as transcription factors. This so-called genomic effect is very slow. Extracellular (non-genomic) steroids bind to neurotransmitter receptors located on the cytoplasmic cell membrane and thus affect ionic channels permeability. Their effect is faster. We refer to them as neuroactive steroids (produced in different body tissues or administered externally) or neurosteroids (synthetized in nervous system cells). Some neuroactive steroids and their metabolites (e.g. progesterone) are crucial in stabilizing the pregnancy. Other steroid disorders play their role in wide spectre of pregnancy complications, such as preterm labor, preeclampsia, intrahepatic cholestasis in pregnancy etc. Our scientific interest in collaboration with the Department of Steroids and Proteofactors of the Institute of Endocrinology in Prague is focused on investigation of multiple pregnancies in term of steroid metabolome. Studies conducted so far have not provided a comprehensive analysis of steroidome within mothers and fetuses of multiple pregnancies. The aim of our research is to clarify the relationship between fetuses and mother from the point...
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Management of Pelvic Organ Prolapse with the Use of Ultrasonography
Smažinka, Martin ; Kališ, Vladimír (advisor) ; Hubka, Petr (referee) ; Urdzík, Peter (referee)
Studies evaluating quality of life are in agreement regarding severity of symptoms and large number of cases of pelvic organs prolapse in women. Therefore, there has been a long- term effort to create optimal approach, including surgical procedures with minimal intra- and posto-perative complications. Historically performed procedures for pelvic organ prolapse (POP) are being either abandoned or modified, with some others becoming obsolete. New materials, especially artificial, have enabled new possibilities in POP management. However, unfortunately, they have also caused new types of complications, which urge the need to carefully consider any surgical indication. Worldwide mostly urogynecology teams are striving to improve the management of POP. In recent years, laparoscopic sacrocolpopexy (LSC SCP) has been performed at our center. This procedure is currently being recognized as the gold standard of surgical care. The main aim of this dissertation thesis is to evaluate surgical management used at our center with the emphasis on the importance of ultrasonographic evaluations during the pre- and posto-perative period and to evaluate its limits and possibilities during the long-term follow- up. The other aim was to determine the incidence of coincidental asymptomatic premalignant and malignant...
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Injury risks and their analysis in czech parkour community
Hubka, Petr ; Gryc, Tomáš (advisor) ; Bačáková, Radka (referee)
Title: Injury risks and their analysis in czech parkour community Objectives: The aim of this bachelor thesis was to find out when, where and how the most common injuries in parkour happen, which individual body segments are most affected and a comparison of injury rates between parkour competitors and non- competitors. Methods: The main methods used were analysis, synthesis and questionnaire survey. The subjects were parkour players aged 15 years and older. The questionnaire survey was used to obtain key information on injuries to recreational and elite parkour athletes. Results: 90% of parkour athletes have suffered at least one injury in the last 3 years of parkour training. The average number of injuries in 3 years of training is for competitive parkour athletes 3.03 and for non-competitive parkour athletes 2.77. The most common type of parkour injury is joint injury i.e. in 44% (n=57 responses). The most common skills that cause injuries in parkour are flips i.e. 36% (n= 40 responses) and jumps (precision, tictac, catleap and others) i.e. 32% (n= 36 responses). The most common place where parkour injuries occur is outdoors, i.e. at 57% (n= 66 responses). The most common body segment injured while doing parkour is the ankle joint (n= 50 responses). The most common cause of injury in parkour is...
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Variation of abnormalities of foramen obturatum and retropubic space and its relation to complications of tape surgery
Hubka, Petr ; Mašata, Jaromír (advisor) ; Smetana, Karel (referee) ; Krofta, Ladislav (referee)
Introduction: The knowledge of anatomy is crucial for introduction of new surgical methods. It is also of especial use while dealing with surgical complications during surgeries with limited surgical field, where the way of approach limits the management of complications. It was assumed that common anatomical variations would influence different efficacy of surgeries and would explain potential complications. Methods: During anatomical dissections fifty female cadavers were dissected and tension-free vaginal tapes TVT-S H, TVT-S U, TVT Abbrevo and Ajust were studied. A novel descriptive system for localisation of the tape was created. During the dissection the tape was located and its localisation and fixation was described. Results: Common anatomical variation in the sample was corona mortis with frequency of 72 %. Preperitoneal fatty plug, which is recognized by some authors as the first stage of obturator hernia, was found in 40 % in obturator canal. The proper fixation of TVT-S H was achieved in 53.6 %. In 10.5 % urinary bladder was injured. In case of TVT-S U the proper fixation occurred in 63.8 %. In two cases the inserter was nearby corona mortis. Within the group of TVTO Abbrevo the tape was fixated properly into the obturator complex (consists of the obturator membrane and obturator muscles) in...
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Variation of abnormalities of foramen obturatum and retropubic space and its relation to complications of tape surgery
Hubka, Petr ; Mašata, Jaromír (advisor) ; Smetana, Karel (referee) ; Krofta, Ladislav (referee)
Introduction: The knowledge of anatomy is crucial for introduction of new surgical methods. It is also of especial use while dealing with surgical complications during surgeries with limited surgical field, where the way of approach limits the management of complications. It was assumed that common anatomical variations would influence different efficacy of surgeries and would explain potential complications. Methods: During anatomical dissections fifty female cadavers were dissected and tension-free vaginal tapes TVT-S H, TVT-S U, TVT Abbrevo and Ajust were studied. A novel descriptive system for localisation of the tape was created. During the dissection the tape was located and its localisation and fixation was described. Results: Common anatomical variation in the sample was corona mortis with frequency of 72 %. Preperitoneal fatty plug, which is recognized by some authors as the first stage of obturator hernia, was found in 40 % in obturator canal. The proper fixation of TVT-S H was achieved in 53.6 %. In 10.5 % urinary bladder was injured. In case of TVT-S U the proper fixation occurred in 63.8 %. In two cases the inserter was nearby corona mortis. Within the group of TVTO Abbrevo the tape was fixated properly into the obturator complex (consists of the obturator membrane and obturator muscles) in...
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