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Possibillities and limitations of short term foster care for chidlren with attachment disorder
Hubáčková, Tereza ; Vodáčková, Daniela (advisor) ; Matoušek, Oldřich (referee)
This bachelor's thesis strives to explore the current issue of short term foster care in relation to children with an attachment disorder and thus contribute towards the ongoing debate about further development of this instrument of social and legal child protection. In the theory part of my thesis, I describe the theory of attachment and explain the term attachment disorder. The next part of my thesis is dedicated to short-term foster care, the exploration of its origin and evolution and the description of its current position. In the practical part of my thesis, I present my qualitative research, which I carried out amongst psychologists and other specialists who actively devote themselves to the issue of children at risk and amongst short term foster parents who have cared for a child with an attachment disorder. I have catalogued the data obtained from semi-structured interviews by means of thematic and narrative analysis, put them into context and drawn from them the answers I had asked at the beginning.
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Possibillities and limitations of short term foster care for chidlren with attachment disorder
Hubáčková, Tereza ; Vodáčková, Daniela (advisor) ; Matoušek, Oldřich (referee)
This bachelor's thesis strives to explore the current issue of short term foster care in relation to children with an attachment disorder and thus contribute towards the ongoing debate about further development of this instrument of social and legal child protection. In the theory part of my thesis, I describe the theory of attachment and explain the term attachment disorder. The next part of my thesis is dedicated to short-term foster care, the exploration of its origin and evolution and the description of its current position. In the practical part of my thesis, I present my qualitative research, which I carried out amongst psychologists and other specialists who actively devote themselves to the issue of children at risk and amongst short term foster parents who have cared for a child with an attachment disorder. I have catalogued the data obtained from semi-structured interviews by means of thematic and narrative analysis, put them into context and drawn from them the answers I had asked at the beginning.
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Role of the ubiquitin-like protein, Hub1, in the pre-mRNA splicing regulation
Hubáčková, Tereza ; Abrhámová, Kateřina (advisor) ; Krchňáková, Zuzana (referee)
Splicing is a key step of eukaryotic gene expression and as well as other steps of this vital process, splicing has to be tightly regulated. Hub1 protein is a ubiquitin-like protein which noncovalently interacts with spliceosomal proteins Snu66 and Prp5 ATPase. According to the proposed model, low level of Hub1 protein stimulates ATPase activity of Prp5 helicase sufficiently for splicing of optimal splice sites, but not for splicing of suboptimal ones. Nevertheless, high level of Hub1 protein stimulates Prp5 ATPase sufficiently for splicing of both splice-site types. Excessive level of Hub1 protein may be harmful for the cell, because the immoderate splicing of suboptimal splice sites may produce aberrantly-spliced transcripts as a by-product. Hub1-induced negative feedback loop safeguards the cell from Hub1 protein hyperactivity by regulation of Prp5 ATPase level. Additionally, Hub1 protein regulates alternative splicing of Saccharomyces cerevisiae SRC1 gene and ensures appropriate balance of its products.
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