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Vliv chemoterapie a genotoxického stresu na imunologické vlastnosti nádorových buněk.
Horňáková, Michaela ; Reiniš, Milan (advisor) ; Drbal, Karel (referee)
Cancer treatment includes the use of chemotherapeutic agents, which have various effects on tumour cells, such as direct toxicity to cancer cells, immunogenic cell death induction and changes in cancer cells phenotype. Throughout the last decade many researchers have been focusing on the induction of genotoxic stress and cellular senescence, which chemotherapy can trigger. Even though induction of senescence in cancer cells represents an important mechanism for tumour suppression, there has been increasing evidence that shifting cancer cells into a senescent state by chemotherapy is not always beneficial. Senescent cells are associated with a specific secretory phenotype, which allows such cells to alter their microenvironment, modulate anti-tumour immunity, induce tumour suppression and even promote cancer development. Therefore, senescent cells elimination by innate or specific immunity, which can be boosted by immunotherapy, can be an important barrier preventing tumour growth. Powered by TCPDF (www.tcpdf.org)
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Vliv chemoterapie a genotoxického stresu na imunologické vlastnosti nádorových buněk.
Horňáková, Michaela ; Reiniš, Milan (advisor) ; Drbal, Karel (referee)
Cancer treatment includes the use of chemotherapeutic agents, which have various effects on tumour cells, such as direct toxicity to cancer cells, immunogenic cell death induction and changes in cancer cells phenotype. Throughout the last decade many researchers have been focusing on the induction of genotoxic stress and cellular senescence, which chemotherapy can trigger. Even though induction of senescence in cancer cells represents an important mechanism for tumour suppression, there has been increasing evidence that shifting cancer cells into a senescent state by chemotherapy is not always beneficial. Senescent cells are associated with a specific secretory phenotype, which allows such cells to alter their microenvironment, modulate anti-tumour immunity, induce tumour suppression and even promote cancer development. Therefore, senescent cells elimination by innate or specific immunity, which can be boosted by immunotherapy, can be an important barrier preventing tumour growth. Powered by TCPDF (www.tcpdf.org)
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Geocaching
Horňáková, Michaela ; Pokorný, Pavel (advisor) ; Jiroušek, Radim (referee)
Geocaching is recently becoming increasingly popular leisure activity in not only in the Czech Republic but also all over the world. Firstly, the work focused on explaining the nature of Geocaching, which deals with finding hidden mailboxes in a given geographical coordinates. Geocaching is not the only activity that is conducted by using GPS navigation but also refers to other options such as Wherigo, GPS Mission etc. The potential use of Geocaching in the commercial sector has not yet been fully exploited, and thus the work also deals with the commercial use of Geocaching which focuses on products and services related to Geocaching. It offers a second option, and commercialization of its substance. The essence is meant mostly concealed caches using GPS, but that does not work under the administration of Groundspeak, the Geocaching shelters. In commercialize the works of nature, especially offers the possibility of using small, but large companies (but also for the faculty) in the form of various competitions and other projects. The thesis is accompanied also by a survey whose results are mentioned through the whole work, i.e. chapters, which were related to the topic of questions in the survey. Results of survey were presented in separate chapters analyzed. Finally created a project called "Discover Jindrichuv Hradec", which is designed to raise awareness of Jindrichuv Hradec or to improve tourism. This project is created precisely to the already mentioned principle of Geocaching, and it has also created a special Web site.
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