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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
BK virus infection in kidney transplant patients.
 Girmanová, Eva ; Viklický, Ondřej (advisor) ; Stříž, Ilja (referee) ; Krejčí, Karel (referee)
Polyoma BK virus is associated with graft dysfunction leading to BK viral nephropathy (BKVN) in 1-10% of kidney transplant recipients, moreover 30-80% of kidney transplant recipients experience asymptomatic reactivation of the virus that does not result in BKV associated damage of the renal allograft. The first aim of this study was to introduce monitoring of BK virus replication in the blood and urine of patients within first year after transplantation. Risk factors were evaluated and limit values for viremia and viruria for BKVN development was established. Positive BK viruria >107 copies/ml and positive BK viremia >104 copies/ml occurred in 25.8% and 5%; respectively. 3 patients out of monitoring study developed BKVN. Using ROC analysis, limit values for the development of BKVN were set at 103 copies/ml serum for BK viremia and 6.7x107 copies/ml BK viruria. The second objective was to determine the expression profile of the immune genes in kidney biopsies in three groups of patients with varying degrees of reactivation of the BK virus (without virus reactivation, with asymptomatic viruria, BKVN). 90 genes of immune response were measured by the TaqMan® low density array RT-qPCR. The analysis of biopsies from patients with non-signalling viruses led to the identification of 5 differentially...
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French Paul on the market of the Czech Republic: enter, operation and other expansion possibilities of this chain of cafés and bakeries
 Girmanová, Eva ; Postler, Milan (advisor) ; Pelantová, Dita (referee)
The bachelor thesis is dealing with the position of the French chain of cafés and bakeries Paul on the market of the Czech Republic. Its target is analysis of the present position on the local market and survey of the expansion possibilities into other places in the capital city and eventually into other cities in the republic. The part of the target is also the survey on the satisfactory of customers, which was realized with the use of questionnaire. The main resource of information was personal experience and the results of the questionnaire. The thesis is divided into theoretical and practical part. The outcome of the survey in the practical part is the satisfactory ratio and suggestions which could heighten its level.
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