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The effects of some flavonoids on isolated rat aortic rings
Fišrová, Martina ; Vopršalová, Marie (advisor) ; Pourová, Jana (referee)
Charles University Faculty of Pharmacy in Hradec Kralove Department of Farmacology & Toxikology Student: Martina Fišrová Supervisor: PharmDr. Marie Vopršalová, CSc. Title of diploma thesis: The effects of some flavonoids on isolated rat aortic rings Flavonoids are secondary plant metabolites that are profusely represented in nature. They are known for their wide range of effects and many of them have beneficial effects on the human body. Above all, they have anti-bacterial and anti-inflammatory properties and effects on cardiovascular system - they cause vasodilation. The aim of this diploma thesis was to investigate vasorelaxation effects of selected flavonoids from the group of flavonolignans - 2,3-dehydrosilybin A (DHS-A), 2,3-dehydrosilybin B (DHS-B) and metabolites, which are components of the silymarin complex found in the plant Silybum marianum (Asteraceae). The vasorelaxation potential of tested substances was verified in ex vivo conditions on isolated rat aortic rings. The effect of increasing doses of individual substances in precontracted aortic rings with intact endothelium was measured. From the measured values, the DRC curves were constructed and EC50 values were determined. The analysis of the results shows, that DHS-A (EC50 = 30,1 mol/l) had the most signifiant activity. Its...
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