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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Thyroid gland and pregnancy
 Christophorou, Neofyta ; Nachtigal, Petr (advisor) ; Rathouská, Jana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of of Biological and Medical Sciences Candidate Neofyta Christophorou Consultant Assoc. Prof. PharmDr. Petr. Nachtigal, Ph.D. Title of Thesis Thyroid gland and pregnancy Thyroid physiology involves a range of biochemical processes in the human body, and is characterized by a respectively wide range of thyroid disorders. Thyroid hormones are produced by the thyroid gland, with through the sequestration of iodine as basic element. This process is regulated both intrathyroidally through enzymatic processes and extrathyroidally through the Hypothalamus-Pituitary-Thyroid-Axis (HPTA). The bioavailability of thyroid hormones and their biological activities in peripheral tissues are regulated by special enzymes called deiodinases. Pregnancy is a state of unique physiological adaptations for both the mother and the fetus that are governed by the maternal-fetal interaction through the placenta. Thyroid hormones are vital in maternal physiology throughout gestation as well as regulators of fetal development. The increased needs in thyroid hormone production during pregnancy pose a stress on thyroid and raise the needs for iodine intake. The inability of the thyroid gland to adapt to this state is marked by increased incidence of...
Detailed record
Thyroid gland and pregnancy
 Christophorou, Neofyta ; Nachtigal, Petr (advisor) ; Rathouská, Jana (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of of Biological and Medical Sciences Candidate Neofyta Christophorou Consultant Assoc. Prof. PharmDr. Petr. Nachtigal, Ph.D. Title of Thesis Thyroid gland and pregnancy Thyroid physiology involves a range of biochemical processes in the human body, and is characterized by a respectively wide range of thyroid disorders. Thyroid hormones are produced by the thyroid gland, with through the sequestration of iodine as basic element. This process is regulated both intrathyroidally through enzymatic processes and extrathyroidally through the Hypothalamus-Pituitary-Thyroid-Axis (HPTA). The bioavailability of thyroid hormones and their biological activities in peripheral tissues are regulated by special enzymes called deiodinases. Pregnancy is a state of unique physiological adaptations for both the mother and the fetus that are governed by the maternal-fetal interaction through the placenta. Thyroid hormones are vital in maternal physiology throughout gestation as well as regulators of fetal development. The increased needs in thyroid hormone production during pregnancy pose a stress on thyroid and raise the needs for iodine intake. The inability of the thyroid gland to adapt to this state is marked by increased incidence of...
Detailed record

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