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Isolation of compounds from Cannabis sativa and their anti-inflammatory effect
Baranová, Zuzana ; Vespalcová, Milena (referee) ; PharmDr.Daniela Veselá (advisor)
The object of this thesis is a traditional and also controversial plant Cannabis sativa. The theoretical part is focused on ubiquitous polyphenolic compounds – flavonoids, also present in the studied plant. All previously researched and confirmed effects on human body are described in detail. The experimental part of this thesis describes the isolation and identification of substances of the chloroform and hexane yields of extract obtained from this plant. Chromatographic methods were used for isolation – thin layer and column chromatography and semipreparative HPLC. Obtained substances were characterized using UV, IR spectrophotometry and NMR. Then the anti-inflammatory activity of obtained substances and also of the ethanolic extract and its yields was observed. The result of the experimental part was the isolation of one pure substance which was identified as the cannabidiolic acid. Using the THP 1 assay, we demonstrated mild anti-inflammatory effect of the non-polar yields and isolated CBDA.
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Usage of Statistical Methods to Assure Capability of Production Process
Kuthanová, Dominika ; Baranová, Zuzana (referee) ; Doubravský, Karel (advisor)
The aim of bachelor´s the thesis is to evaluate the quality of production using tools of statistical process control and to propose possible measures leading to its improvement. The thesis uses the following statistical tools: control charts, normality tests and capability indexes. The bachelor´s thesis also clarifies the principle of Six Sigma methodology. The output of the thesis is the proposed application of following tools: target control carts and the Cpm index for statistical process control of the researched company.
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Isolation of compounds from Cannabis sativa and their biological effect
Baranová, Zuzana ; Vespalcová, Milena (referee) ; Šmejkal,, Karel (advisor)
The object of this thesis is a traditional and also controversial plant Cannabis sativa. The theoretical part is focused on botanical side of this plant and its presently used medical forms. All previously isolated substances and their observed biological activity are described in detail. The experimental part of this thesis describes the isolation and identification of substances of the chloroform extract fraction obtained from this plant. Chromatographic methods were used for isolation – analytical and semipreparative HPLC. Obtained substances were identified using UV and IR spectrophotometry. Then the biological effect of obtained substances was observed on chosen microorganisms.
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Water Treatment Plants and their Failure Modes
Baranová, Zuzana ; Anderle, Lukáš (referee) ; Kučera, Tomáš (advisor)
The aim of this thesis was to conduct a survey in selected water treatment plants to identify possible faults with which treatment providers may encounter. Within the thesis has been visited these treatments: ÚV Troubky, ÚV Hosov, ÚV Příkazy, ÚV Černovír. Further was performed evaluation of the collected information, specification and frequency disturbances occurring on those premises.
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Coexceedance in financial markets of countries trying to join the European Union
Baranová, Zuzana ; Horváth, Roman (advisor) ; Dědek, Oldřich (referee)
This thesis analyses financial contagion between a reference EU market - Germany and markets of five countries which are actively seeking to become a part of European Union - Montenegro, Serbia, Turkey, Bosnia and Macedonia in the period of March 2006 to March 2018. We apply quantile regression framework to analyse contagion which we base on the occurrence and degree of coexceedances between the reference and analysed market. The results indicate that contagion between stock markets exists, however in different degree for each of the analysed markets. In addition we apply the regression framework specifically for period of financial crisis of 2008 to demonstrate that contagion is stronger during turbulent market periods. JEL Classification G01, G14, G15 Keywords coexceedance, quantile regression, contagion, stock markets Author's e-mail 80605682@fsv.cuni.cz Supervisor's e-mail roman.horvath@fsv.cuni.cz
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Usage of Statistical Methods to Assure Capability of Production Process
Kuthanová, Dominika ; Baranová, Zuzana (referee) ; Doubravský, Karel (advisor)
The aim of bachelor´s the thesis is to evaluate the quality of production using tools of statistical process control and to propose possible measures leading to its improvement. The thesis uses the following statistical tools: control charts, normality tests and capability indexes. The bachelor´s thesis also clarifies the principle of Six Sigma methodology. The output of the thesis is the proposed application of following tools: target control carts and the Cpm index for statistical process control of the researched company.
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|
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Water Treatment Plants and their Failure Modes
Baranová, Zuzana ; Anderle, Lukáš (referee) ; Kučera, Tomáš (advisor)
The aim of this thesis was to conduct a survey in selected water treatment plants to identify possible faults with which treatment providers may encounter. Within the thesis has been visited these treatments: ÚV Troubky, ÚV Hosov, ÚV Příkazy, ÚV Černovír. Further was performed evaluation of the collected information, specification and frequency disturbances occurring on those premises.
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Isolation of compounds from Cannabis sativa and their anti-inflammatory effect
Baranová, Zuzana ; Vespalcová, Milena (referee) ; PharmDr.Daniela Veselá (advisor)
The object of this thesis is a traditional and also controversial plant Cannabis sativa. The theoretical part is focused on ubiquitous polyphenolic compounds – flavonoids, also present in the studied plant. All previously researched and confirmed effects on human body are described in detail. The experimental part of this thesis describes the isolation and identification of substances of the chloroform and hexane yields of extract obtained from this plant. Chromatographic methods were used for isolation – thin layer and column chromatography and semipreparative HPLC. Obtained substances were characterized using UV, IR spectrophotometry and NMR. Then the anti-inflammatory activity of obtained substances and also of the ethanolic extract and its yields was observed. The result of the experimental part was the isolation of one pure substance which was identified as the cannabidiolic acid. Using the THP 1 assay, we demonstrated mild anti-inflammatory effect of the non-polar yields and isolated CBDA.
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Isolation of compounds from Cannabis sativa and their biological effect
Baranová, Zuzana ; Vespalcová, Milena (referee) ; Šmejkal,, Karel (advisor)
The object of this thesis is a traditional and also controversial plant Cannabis sativa. The theoretical part is focused on botanical side of this plant and its presently used medical forms. All previously isolated substances and their observed biological activity are described in detail. The experimental part of this thesis describes the isolation and identification of substances of the chloroform extract fraction obtained from this plant. Chromatographic methods were used for isolation – analytical and semipreparative HPLC. Obtained substances were identified using UV and IR spectrophotometry. Then the biological effect of obtained substances was observed on chosen microorganisms.
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