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Preclinical atherosclerosis of peripheral arteries and its relation to venous thrombosis in patiens with thrombophilias
Auzký, Ondřej ; Piťha, Jan (advisor) ; Karetová, Debora (referee) ; Vaverková, Helena (referee)
The aim of our study was to evaluate association between venous disorders and preclinical atherosclerosis and its risk factors. The study was particularly focused on the association between cardiovascular risk factors and preclinical atherosclerosis with venous diseases represented by venous thromboembolism and/or symptoms of chronic venous disease evaluated by standard protocol. In our first study we evaluated the association between preclinical atherosclerosis and prevalence of venous thromboembolic events in patients with thrombophilias. Preclinical atherosclerosis might increase through its procoagulative action the risk of venous thromboembolism. Presence of preclinical atherosclerosis in common carotid and femoral arteries measured by ultrasound was assessed by Belcaro score (based mainly on presence of plaques) and by measurements of intima media thickness in the same location in 109 patients (43 men, mean age 41.5 ± 13 years) with established thrombophilias. Other parameters under study were age, presence of traditional cardiovascular risk factors, anthropometric and clinical data including blood pressure measurements and medication. The differences between 4 patients with (n = 47) and without (n = 62) thromboembolic events were assessed by paired t-test and chi square tests. In patients with a...
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Epidemiological research methods in cardiovascular diseases
Špecián, Miroslav ; Auzký, Ondřej (advisor) ; Čelko, Alexander (referee)
This bachelor paper focuses on the epidemiological methods in the research of cardiovascular diseases. Using 3 cardiovascular diagnosis (acute myocardial infarction, heart arrest and atherosclerosis) as a background, it illustrates individual research designs (types of studies), namely: case report, case series, case-control study, cross-sectional study, cohort study, randomized (controlled) trial and systematic review/metaanalysis. Each of these designs is illustrated by the specific example of a previously performed study. The paper also observes the features distinguishing epidemiological and clinical approaches to medicine and discusses the relation between epidemiology and evidence base medicine (EBM).
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Epidemiological research methods in cardiovascular diseases
Špecián, Miroslav ; Auzký, Ondřej (advisor) ; Čelko, Alexander (referee)
This bachelor paper focuses on the epidemiological methods in the research of cardiovascular diseases. Using 3 cardiovascular diagnosis (acute myocardial infarction, heart arrest and atherosclerosis) as a background, it illustrates individual research designs (types of studies), namely: case report, case series, case-control study, cross-sectional study, cohort study, randomized (controlled) trial and systematic review/metaanalysis. Each of these designs is illustrated by the specific example of a previously performed study. The paper also observes the features distinguishing epidemiological and clinical approaches to medicine and discusses the relation between epidemiology and evidence base medicine (EBM).
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Preclinical atherosclerosis of peripheral arteries and its relation to venous thrombosis in patiens with thrombophilias
Auzký, Ondřej ; Piťha, Jan (advisor) ; Karetová, Debora (referee) ; Vaverková, Helena (referee)
The aim of our study was to evaluate association between venous disorders and preclinical atherosclerosis and its risk factors. The study was particularly focused on the association between cardiovascular risk factors and preclinical atherosclerosis with venous diseases represented by venous thromboembolism and/or symptoms of chronic venous disease evaluated by standard protocol. In our first study we evaluated the association between preclinical atherosclerosis and prevalence of venous thromboembolic events in patients with thrombophilias. Preclinical atherosclerosis might increase through its procoagulative action the risk of venous thromboembolism. Presence of preclinical atherosclerosis in common carotid and femoral arteries measured by ultrasound was assessed by Belcaro score (based mainly on presence of plaques) and by measurements of intima media thickness in the same location in 109 patients (43 men, mean age 41.5 ± 13 years) with established thrombophilias. Other parameters under study were age, presence of traditional cardiovascular risk factors, anthropometric and clinical data including blood pressure measurements and medication. The differences between 4 patients with (n = 47) and without (n = 62) thromboembolic events were assessed by paired t-test and chi square tests. In patients with a...
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