|
|
Structural and functional impacts of infective endocarditis
Pazderník, Michal ; Šochman, Jan (advisor) ; Veselka, Josef (referee) ; Beneš, Jiří (referee)
Despite more recent advances in both medical and surgical therapies, the syndrome of infective endocarditis (IE) continues to be characterized by serious complications, and remains a life-threatening infection. According to data from the World Health Organization, the Czech Republic has one of the highest mortality rates due to this disease worldwide. Despite the severity of illness in this country, very few data have been reported previously regarding investigations of IE in the Czech Republic. Consequently, a retrospective evaluation of local IE cases at one of the country's largest medical centers was conducted. Our aim was to analyze the characteristics of this disease in our country. The greatest interest was devoted to Staphylococcus aureus (S. aureus), etiological agent that has been associated with the worst course of IE episodes. The hypothesis of our study was that infective endocarditis caused by S. aureus, in comparison with other etiological agents, is associated with worse course of the disease. We evaluated the structural (abscess formation, impaired integrity of heart valves, systemic embolism) and functional (incidence of heart failure and conduction disturbances, in-hospital mortality) manifestations of IE. Of all studied parameters, only embolism and S. aureus as the causative agent were...
|
|
|
Resistance to antiplatelet therapy in cardiovascular diseases management
Ševčíková, Hana ; Vojáček, Jan (advisor) ; Šochman, Jan (referee) ; Vítovec, Jiří (referee)
Summary: Introduction: Antiplatelet therapy is a cornerstone in the management of cardiovascular diseases. With regard to interindividual variability in platelet reactivity and recurrence of thrombotic events despite therapy the importance of platelet function monitoring seems to be much higher. Objectives: The aim of our study was to describe the prevalence of high on treatment platelet reactivity in our study population. We were looking for the potential relationship between platelet reactivity and comorbidities or medication and tried to assess measurement reproducibility. Methods and results: 207 patients with cardiovascular diseases on ASA treatment (daily dose 100mg) were enrolled. Platelet functions were monitored by optic aggregometry (LTA) with cationic propylgallate as inductor. Residual platelet reactivity was assessed initially and afterwards (median value 9 months) without changes in ASA dose. In 82,1% suppression of platelet reactivity was adequate in both assessments, in 16,9% suppression of platelet reactivity was inadequate in at least one of the measurements. Our results show wide variability in platelet reactivity in time (p=0,67). No statistically significant differences in platelet reactivity were found in subpopulation with acute coronary syndromes (p=0,37), with chronic stable...
|
|
|
Structural and functional impacts of infective endocarditis
Pazderník, Michal ; Šochman, Jan (advisor) ; Veselka, Josef (referee) ; Beneš, Jiří (referee)
Despite more recent advances in both medical and surgical therapies, the syndrome of infective endocarditis (IE) continues to be characterized by serious complications, and remains a life-threatening infection. According to data from the World Health Organization, the Czech Republic has one of the highest mortality rates due to this disease worldwide. Despite the severity of illness in this country, very few data have been reported previously regarding investigations of IE in the Czech Republic. Consequently, a retrospective evaluation of local IE cases at one of the country's largest medical centers was conducted. Our aim was to analyze the characteristics of this disease in our country. The greatest interest was devoted to Staphylococcus aureus (S. aureus), etiological agent that has been associated with the worst course of IE episodes. The hypothesis of our study was that infective endocarditis caused by S. aureus, in comparison with other etiological agents, is associated with worse course of the disease. We evaluated the structural (abscess formation, impaired integrity of heart valves, systemic embolism) and functional (incidence of heart failure and conduction disturbances, in-hospital mortality) manifestations of IE. Of all studied parameters, only embolism and S. aureus as the causative agent were...
|
|
| |
guest ::
