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The Chronic Wound Therapy
Prosková, Zuzana ; Semecký, Vladimír (advisor) ; Martiník, Karel (referee)
The chronic wound is a secondarily healing wound, which didn't healed during 6 - 9 weeks despite adequate healing. Chronic wounds grow up from the acute wound crossing into chronicity as a result of an illness or an infection. The aim is to heal not only the defect but the illness as a complex. The suitable media of wound is necessary for re-issue of healing process. The balance and distribudion of MMPs and TIMPs is breaked in benefit of MMPs in non-healing wounds. In chronic wound liquids there are increased levels of MMP-2 and MMP-9. More increased proteases MMP-1, MMP-2, MMP-8, MMP-9, MMP-13, neutrophil elastese, uPA can be found directly in the chronic wound. That leads into substrates degradation which are necessary for healing (colagen, gelatin et al.). There was found out, that the decreasing of pH media leads to the decreasing of proteasis activity. The optimal pH of the media is 4 - 7. The epidermal growing factor is significantly more degraded and that leads into inhibition of proliferation of epidermal cells The experimental part target for healing by "wet" therapy. By all twelve pacients there were focused cleaning of wound, and regulation of a wound internal balance. The wound reparation was started. The contition is the right choise of "protection" for the concrete fase of healing....
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The Chronic Wound Therapy
Prosková, Zuzana ; Semecký, Vladimír (advisor) ; Martiník, Karel (referee)
The chronic wound is a secondarily healing wound, which didn't healed during 6 - 9 weeks despite adequate healing. Chronic wounds grow up from the acute wound crossing into chronicity as a result of an illness or an infection. The aim is to heal not only the defect but the illness as a complex. The suitable media of wound is necessary for re-issue of healing process. The balance and distribudion of MMPs and TIMPs is breaked in benefit of MMPs in non-healing wounds. In chronic wound liquids there are increased levels of MMP-2 and MMP-9. More increased proteases MMP-1, MMP-2, MMP-8, MMP-9, MMP-13, neutrophil elastese, uPA can be found directly in the chronic wound. That leads into substrates degradation which are necessary for healing (colagen, gelatin et al.). There was found out, that the decreasing of pH media leads to the decreasing of proteasis activity. The optimal pH of the media is 4 - 7. The epidermal growing factor is significantly more degraded and that leads into inhibition of proliferation of epidermal cells The experimental part target for healing by "wet" therapy. By all twelve pacients there were focused cleaning of wound, and regulation of a wound internal balance. The wound reparation was started. The contition is the right choise of "protection" for the concrete fase of healing....
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