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Evaluation of compressibility of granular powders and tableting mixtures with the high content of active substance.
Paris, Tereza ; Svačinová, Petra (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department od: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Tereza Paris Title of Thesis: Evaluation of compressibility of granular powders and tableting mixtures with the high content of active substance This thesis deals with the evaluation of compressibility of granular powder and tableting mixtures with high drug content. Eleven batches of tablet formulations with different type of filler - microcrystalline cellulose or lactose and different type of extragranular disintegrants - sodium croscarmellose or crospovidone in concentrations of 2 %, 3,7 % or 5,4 % and two granular powders with only different type of filler were prepared by two methods. The first method was used to prepare tablets with the same height and the second method to prepare tablets with the same porosity as the oval tablets made from identical tableting mixtures. The compressibility was evaluated using the force-displacement method parameters and volumetric elastic recovery. Another tested parameter was tensile strength and, for one group of tablets, also porosity. The obtained results show that both, the type of filler and the type of extragranular disintegrant, had an effect on the force-displacement method parameters especially at...
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