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A study of the compressibility and properties of tablets from co-processed dry binder composed of microcrystalline cellulose and glyceryl monostearate.
Muchová, Sandra ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
The paper studies the co-processed dry binder LubriTose™ MCC from the viewpoint of energy evaluation of the compression process, strength and disintegration time of tablets. The results were compared with the identical evaluation of physical mixtures of microcrystalline cellulose with several types of lubricants. LubriTose™ MCC showed the lowest value of energy for friction, the highest value of energy accumulated by the tablet, and the highest plasticity of all tableting materials under study. There were no marked differences in the values of the energy of decompression. The tensile strength of tablets from LubriTose™ MCC was lower than in those from the mixture of Vivapur® 12 and glycerol monostearate, in the compression forces of 4 and 5 kN it was comparable with the tensile strength of tablets from Vivapur® 12 with poloxamer 407. Disintegration time of tablets from LubriTose™ MCC was shorter than that of those from Vivapur® 12 with glycerol monostearate at the compression force of 3 kN, in the case of the compression forces of 4 and 5 kN no statistically significant difference was found between the values of these tableting materials.
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The study of matrix lipophilic tablets with glyceryl behenate
Muchová, Sandra ; Mužíková, Jitka (advisor) ; Dittrich, Milan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical technology Candidate Mgr. Sandra Muchová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Thesis The study of matrix lipophilic tablets with glyceryl behenate The thesis studies the compressibility of directly compressible tableting materials with the dry binder spray-dried lactose and microcrystalline cellulose and various concentrations of glyceryl behenate. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. The rate of release of the active ingredient salicylic acid from tablets was also examined. Glyceryl behenate influenced compressibility of tableting materials with microcrystalline cellulose more than those with spray-dried lactose. Increasing concentrations of glyceryl behenate prolonged the release of salicylic acid, but there was no statistically significant difference within the type of the dry binder used.
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The study of matrix lipophilic tablets with glyceryl behenate
Muchová, Sandra ; Mužíková, Jitka (advisor) ; Dittrich, Milan (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical technology Candidate Mgr. Sandra Muchová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Thesis The study of matrix lipophilic tablets with glyceryl behenate The thesis studies the compressibility of directly compressible tableting materials with the dry binder spray-dried lactose and microcrystalline cellulose and various concentrations of glyceryl behenate. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. The rate of release of the active ingredient salicylic acid from tablets was also examined. Glyceryl behenate influenced compressibility of tableting materials with microcrystalline cellulose more than those with spray-dried lactose. Increasing concentrations of glyceryl behenate prolonged the release of salicylic acid, but there was no statistically significant difference within the type of the dry binder used.
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A study of the compressibility and properties of tablets from co-processed dry binder composed of microcrystalline cellulose and glyceryl monostearate.
Muchová, Sandra ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
The paper studies the co-processed dry binder LubriTose™ MCC from the viewpoint of energy evaluation of the compression process, strength and disintegration time of tablets. The results were compared with the identical evaluation of physical mixtures of microcrystalline cellulose with several types of lubricants. LubriTose™ MCC showed the lowest value of energy for friction, the highest value of energy accumulated by the tablet, and the highest plasticity of all tableting materials under study. There were no marked differences in the values of the energy of decompression. The tensile strength of tablets from LubriTose™ MCC was lower than in those from the mixture of Vivapur® 12 and glycerol monostearate, in the compression forces of 4 and 5 kN it was comparable with the tensile strength of tablets from Vivapur® 12 with poloxamer 407. Disintegration time of tablets from LubriTose™ MCC was shorter than that of those from Vivapur® 12 with glycerol monostearate at the compression force of 3 kN, in the case of the compression forces of 4 and 5 kN no statistically significant difference was found between the values of these tableting materials.
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