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A Study of the Properties of Tablets from two Types of Microcrystalline Cellulose
Lišková, Simona ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
The thesis studies mechanical strenght and disintegration time of tablets from two types of Microcel - Microcel® MC - 12 a Microcel® MC - 500. These characteristics were studied depending on compression force (3, 4 and 5 kN) and addition of two types of lubricants (magnesium stearate, natrium stearyl fumarate) in two concentrations - 0, 5 % and 1 % and addition of two model active substances in concentration 50 % (acetylsalicylic acid and ascorbic acid). For compression with active substance the compression force of 5 kN was used. It was found that tablets from Microcel® MC - 12 had higher mechanical strenght than the tablets from Microcel® MC - 500. The mechanical strenght was markedly lower by the addition of lubricants in tablets using both types of Microcel. Microcel® MC - 500 was more sensitive to addition of the lubricants. Sensitivity was as higher as the concentration of lubricant was stronger. Addition of magnesium stearate made tablets of lower compactability. Also disintegration time of both types of tablets was shorter with addition of lubricant. With using Microcel® MC - 12 disintegration time was a little longer. In the case of using Souhrn 86 magnesium stearate as a lubricant in the concentration of 1 % the disintegration time was the shortest. Tablets from Microcel® MC - 12 and with...
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A study of the properties of compacts from directly compressible fructose.
Lišková, Simona ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
In this work is studied mechanical strenght an disintegration time of tablets from direct compressed fructose - Advantose ™ FS 95, prepared by coprocessing method of spray- drying of fructose and a small amount of starch and its mixture with microcrystalline cellulose Vivapur 102 in the ratio of 1:1 according to the compression force 10, 12,5 and 15 kN, addition of two lubricants (magnesium stearate, Pruv) in the same concentration 1% and addition of two model active substances (acetylsalicylic acid and ascorbic acid) in the concentration 50%. Used compression force for compression of mixtures with active substances was 12,5kN. There was no statistically significant difference in values of mechanical strenght of tablets from Advantose FS 95 in terms of type of used lubricant except for the compression force 10 kN. Tablets from the mixture of Advantose FS 95 and Vivapur 102 in the ratio of 1:1 had higher mechanical strenght than the tablets only from Advantose FS 95 . Nevertheless the mechanical strenght was markedly lower by the addition of lubricants and more by the addition of magnesium stearate. Disintegration time was prolonged by the addition of lubricants in the case of tablets with Advantose FS 95 and its mixture with Vivapur 102. The longest disentigration time had the tablets from the...
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Possibilities of teaching work with a map at primary and secondary schools
Lišková, Simona ; Hanus, Martin (advisor) ; Novotná, Kateřina (referee)
The theme of this work are possibilities of teaching work with a map at elementary and secondary schools. It deals with the development of pupils' map skills in the subjects of geography, biology, history and mathematics at primary and secondary schools. Map skills are often seen as a part of geographic skills and in the Czech Republic they have not been adequately investigated yet. The theoretical part deals with the definition and classification of map skills based on discussions with the literature. The work also contains analysis of Czech and American curricula according to the selected classification. Analysis of these documents summarizes the teaching map skills of pupils aged 11, 15 and 18-20. Worksheets designed for the development of pupils' map skills at the end of the first and second grade of elementary schools (in the Czech Republic - pupils aged 11 and 15) and at the end of grammar schools (pupils aged 18-20) are presented in the practical part of this work. Worksheets develop pupils' map skills according to the selected model of map skills classification. These worksheets could be used by teachers to teach the working with maps at primary and secondary schools. Keywords: Geography - Geography (as the school subject) - homeland - skill - cartography - map - a map skills - reading maps...
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A study of the properties of compacts from directly compressible fructose.
Lišková, Simona ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
In this work is studied mechanical strenght an disintegration time of tablets from direct compressed fructose - Advantose ™ FS 95, prepared by coprocessing method of spray- drying of fructose and a small amount of starch and its mixture with microcrystalline cellulose Vivapur 102 in the ratio of 1:1 according to the compression force 10, 12,5 and 15 kN, addition of two lubricants (magnesium stearate, Pruv) in the same concentration 1% and addition of two model active substances (acetylsalicylic acid and ascorbic acid) in the concentration 50%. Used compression force for compression of mixtures with active substances was 12,5kN. There was no statistically significant difference in values of mechanical strenght of tablets from Advantose FS 95 in terms of type of used lubricant except for the compression force 10 kN. Tablets from the mixture of Advantose FS 95 and Vivapur 102 in the ratio of 1:1 had higher mechanical strenght than the tablets only from Advantose FS 95 . Nevertheless the mechanical strenght was markedly lower by the addition of lubricants and more by the addition of magnesium stearate. Disintegration time was prolonged by the addition of lubricants in the case of tablets with Advantose FS 95 and its mixture with Vivapur 102. The longest disentigration time had the tablets from the...
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A Study of the Properties of Tablets from two Types of Microcrystalline Cellulose
Lišková, Simona ; Šnejdrová, Eva (referee) ; Mužíková, Jitka (advisor)
The thesis studies mechanical strenght and disintegration time of tablets from two types of Microcel - Microcel® MC - 12 a Microcel® MC - 500. These characteristics were studied depending on compression force (3, 4 and 5 kN) and addition of two types of lubricants (magnesium stearate, natrium stearyl fumarate) in two concentrations - 0, 5 % and 1 % and addition of two model active substances in concentration 50 % (acetylsalicylic acid and ascorbic acid). For compression with active substance the compression force of 5 kN was used. It was found that tablets from Microcel® MC - 12 had higher mechanical strenght than the tablets from Microcel® MC - 500. The mechanical strenght was markedly lower by the addition of lubricants in tablets using both types of Microcel. Microcel® MC - 500 was more sensitive to addition of the lubricants. Sensitivity was as higher as the concentration of lubricant was stronger. Addition of magnesium stearate made tablets of lower compactability. Also disintegration time of both types of tablets was shorter with addition of lubricant. With using Microcel® MC - 12 disintegration time was a little longer. In the case of using Souhrn 86 magnesium stearate as a lubricant in the concentration of 1 % the disintegration time was the shortest. Tablets from Microcel® MC - 12 and with...
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