|
|
Age-related macular degeneration and therapeutic possibilities to influence the wet form of the disease
Fric, Evžen ; Langrová, Hana (advisor) ; Boguszaková, Jarmila (referee) ; Karel, Ivan (referee)
In our study we evaluated the functional and anatomical parameters in patients presenting with the wet form of ARMD treated by TTT, PDT or intravitreal administration of bavacizumab in the follow-up period of 12 months. In the group treated by TTT we found significant decrease of best corrected visual acuity (BCVA) within the follow-up period. In the group of patients with classic CNV treated by PDT, the resulting median of BCVA was the same as at the beginning. Therefore the PDT can stabilize BCVA, but cannot improve it. However, statistically significant improvement of BCVA was observed in the group of patients with ocult CNV treated with intravitreal administration of bevacizumab. BCVA was statistically insignificant between the groups at the initial visit, with the exception of significantly lower values in patients treated by TTT in comparison with those treated by PDT. After 6 and 12 months, the BCVA differences were only nonsignificant between TTT and PDT groups. In the group with classic CNV treated by PDT or TTT the difference in BCVA was not statistically significant, as well; on the other hand, the BCVA was significantly better in patients with occult CNV treated by bevacizumab in comparison with the patients treated by PDT or TTT. The best anatomical outcomes evaluated according to FAG...
|
|
|
Age-related macular degeneration and therapeutic possibilities to influence the wet form of the disease
Fric, Evžen ; Langrová, Hana (advisor) ; Boguszaková, Jarmila (referee) ; Karel, Ivan (referee)
In our study we evaluated the functional and anatomical parameters in patients presenting with the wet form of ARMD treated by TTT, PDT or intravitreal administration of bavacizumab in the follow-up period of 12 months. In the group treated by TTT we found significant decrease of best corrected visual acuity (BCVA) within the follow-up period. In the group of patients with classic CNV treated by PDT, the resulting median of BCVA was the same as at the beginning. Therefore the PDT can stabilize BCVA, but cannot improve it. However, statistically significant improvement of BCVA was observed in the group of patients with ocult CNV treated with intravitreal administration of bevacizumab. BCVA was statistically insignificant between the groups at the initial visit, with the exception of significantly lower values in patients treated by TTT in comparison with those treated by PDT. After 6 and 12 months, the BCVA differences were only nonsignificant between TTT and PDT groups. In the group with classic CNV treated by PDT or TTT the difference in BCVA was not statistically significant, as well; on the other hand, the BCVA was significantly better in patients with occult CNV treated by bevacizumab in comparison with the patients treated by PDT or TTT. The best anatomical outcomes evaluated according to FAG...
|
guest ::
