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Nanoparticle Generation for Follow-Up Exposure Studies by Oxidation of Copper Acetylacetonate.
Moravec, Pavel ; Schwarz, Jaroslav ; Vodička, Petr ; Švehla, Jaroslav ; Kupčík, Jaroslav
The exposure to nanoparticles (NPs) represents a severe problem to human health, because they are becoming more widely used and their number of applications continually increases. Particles containing copper are emitted from smelters, iron foundries, power stations and municipal incinerators (WHO, 1998), as well as from brake linings during braking, Kukutschova et al. (2011). Copper and copper oxide NPs are frequently used as catalysts, heat transfer fluids in machine tools (Kim et al., 2011), inks, anode material in lithium-ion batteries (Guo et al., 2002) and many others. Even though CuO NPs were found highly toxic, Karlsson et al. (2008) and it is likely that NPs enter human body via respiratory tract, the inhalation exposure experiments of CuO NPs with laboratory animals are still rather rare (Pettibone et al., 2008 and Lebedova et al., 2016). The exposure chamber for long lasting inhalation experiments was constructed at the Institute of Analytical Chemistry of the CAS (Večeřa et al., 2011) and some methods of NPs generation for these experiments were already tested in our laboratory (Moravec et al., 2015 and Moravec et al., 2016a). The generation of Cu/Cu2O NPs by thermal decomposition of copper acetylacetonate (CuAA) was reported by Moravec et al. (2016b) and here we present the results of long lasting generation of NPs by oxidation of CuAA.
Plný tet: SKMBT_C22017103113062 -  PDF
Plný text: content.csg - PDF
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Generation of NPS for Exposure Experiments from Copper Acetylacetone.
Moravec, P. ; Schwarz, J. ; Vodička, P. ; Kupčík, Jaroslav ; Švehla, J.
Particles containing copper are emitted from smelters, iron foundries, power stations, and municipal incinerators (WHO, 1998) and also from brake linings during breaking, Kukutschová et al. (2011). Nanoparticles (NPs) of copper are ingredients in polymers, inks, and bioactive coatings inhibiting the growth of microorganisms, Cioffi at al. (2005), and CuO NPs has been used in antimicrobial textiles, Gabbay and Borkow (2006), therefore they can be easily inhaled. Even though CuO NPs were found highly toxic, Karlsson et al. (2008), in vivo studies of their toxicity are still rather rare. In this work we tested a method of long lasting nanoparticle generation from copper acetylacetonate (CuAA) for use in follow up exposure experiments with laboratory animals. The exposure chamber for inhalation experiments was constructed in the Institute of Analytical Chemistry AS CR (Večeřa et al., 2011) and some methods of NPs generation for these experiments were already tested in our laboratory (Moravec et al., 2015, Moravec et al., 2016).
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Generation of NPS for Exposure Experiments from Copper Acetylacetone.
Moravec, Pavel ; Schwarz, Jaroslav ; Vodička, Petr ; Kupčík, Jaroslav ; Švehla, Jaroslav
Particles containing copper are emitted from smelters, iron foundries, power stations, and municipal incinerators (WHO, 1998) and also from brake linings during breaking, Kukutschová et al. (2011). Nanoparticles (NPs) of copper are ingredients in polymers, inks, and bioactive coatings inhibiting the growth of microorganisms, Cioffi at al. (2005), and CuO NPs has been used in antimicrobial textiles, Gabbay and Borkow (2006), therefore they can be easily inhaled. Even though CuO NPs were found highly toxic, Karlsson et al. (2008), in vivo studies of their toxicity are still rather rare. In this work we tested a method of long lasting nanoparticle generation from copper\nacetylacetonate (CuAA) for use in follow up exposure experiments with laboratory animals. The exposure chamber for inhalation experiments was constructed in the\nInstitute of Analytical Chemistry AS CR (Večeřa et al., 2011) and some methods of NPs generation for these experiments were already tested in our laboratory (Moravec et al., 2015, Moravec et al., 2016).
Plný tet: SKMBT_C22016102412242 - PDF
Plný text: content.csg - PDF
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Long Lasting ZnO Nanoparticle Synthesis for Potential Use in Inhalation Experiments
Moravec, Pavel ; Kupčík, Jaroslav
In this work we tested the long term generation of ZnO-NPs for potential use in exposure experiments with laboratory animals. These experiments require the generation of NPs in the gas phase with appropriate number concentration (Nt>1 107 #/cm3) and geometric mean diameter (GMD<50 nm) in duration of several weeks. Several methods of gas phase ZnO-NPs synthesis using metalorganic precursors, such as zinc acetylacetonate, zinc tetramethylheptane dionate or diethylzinc were reported in the literature. However, NPs prepared from metalorganic precursor are usually more or less contaminated by elemental (EC) or organic (OC) carbon. Therefore we used metallic zinc as a precursor in this study.
Plný tet: SKMBT_C22015102910283 - PDF
Plný text: content.csg - PDF
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Generation of TiO2 Nanoparticles for Follow-Up Inhalation Experiments with Laboratory Animals
Moravec, Pavel ; Schwarz, Jaroslav ; Vodička, Petr ; Koštejn, Martin
A method of TiO2 nanoparticle generation appropriate for follow-up long lasting inhalation experiments with laboratory animals was tested. Nanoparticles were synthesized in an externally heated tube reactor using titanium tetraisopropoxide as a precursor. Total 264 hours of particle generation in four experimental campaigns was performed with one batch of precursor without observable decrease of precursor volatility. Particle production was studied in wide range of experimental conditions such as reactor temperature, reactor flow rate and precursor vapor pressure by pyrolysis, using nitrogen as a carrier gas, and also in oxidizing atmosphere (10 vol. % of oxygen in the reaction mixture). Particle characteristics were investigated by scanning/transmission electron microscopy, energy dispersive spectroscopy, inductively coupled plasma optical emission spectrometry, elemental and organic carbon analyzer, X-ray diffraction and X-ray photoelectron spectrometry. As a result, particle production with number concentration high above 1.0 x 10(7) #/cm(3) and with primary particle size well below 50 nm can be easily achieved in most of investigated experimental conditions. Particles are free of elemental carbon, content of organic carbon is less than 10 weight %, detected crystalline phase is typically anatase, Ti is present in bonds Ti-O (TiO2) and total Ti concentration recalculated on TiO2 is approximately 80 mass %.
Plný tet: SKMBT_C22015041615090 - PDF
Plný text: content.csg - PDF
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Nanoparticle Formation by Thermal Decomposition and Oxidation of Manganese(II) Acetylacetonate
Moravec, Pavel ; Smolík, Jiří ; Bakardjieva, Snejana ; Levdansky, V.V.
Over the last decade, Mn and MnOx nanoparticles has been extensively investigated due to their great importance in catalysis, electrochemistry, ion exchange materials, batteries and other areas (Si et al., 2005; Han et al., 2006). This work describes preliminary experiments producing manganese nanoparticles by metal organic chemical vapor deposition (MOCVD) using manganese(II) acetylacetonate (MnAA) as a precursor.
Plný tet: SKMBT_C22012102615333 - PDF
Plný text: content.csg - PDF
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Generation of Binary COOx/SiO2 Nanoparticles from Organocompound Precursors
Moravec, Pavel ; Smolík, Jiří ; Bakardjieva, Snejana ; Levdansky, V.V.
In recent years cobalt and cobalt oxide nanoparticles have attracted substantial research effort because of their potential applications such as protective materials, catalysts, magnetic data recorders, batteries and gas sensors (Jang et al., 2004). To improve their functionality and biocompatibility nanoparticles are frequently coated with SiO2 (Teleki et al., 2008). In this work, we studied CoOx-SiO2 binary nanoparticles synthesis by metal organics chemical vapor deposition (MOCVD) using organo-compound precursors cobalt acetylacetonate (CoAA) and tetraethyl orthosilicate (TEOS).
Plný text: PDF
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