National Repository of Grey Literature 612 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
The Optimization of Logistics Processes in the Selected company
Pecina, Miroslav ; Juřica, Pavel (referee) ; Bartošek, Vladimír (advisor)
This thesis is trying to solve logistics problém in Mountfield a.s. Therse problems results in late delivery of the goods to customer, this fact causes negative evaluation from the purchase. Current problem follow old rules which do not manage to respond to the growing demand from customerss. In the design part these problem is solved with cooperation between store branch
Construction and building of a wind turbine
Pavlík, Šimon ; Linda, Jakub (referee) ; Škorpík, Jiří (advisor)
The aim of the bachelor thesis is to write a background research which deals with construction and building process of big wind turbines. The theory of potential wind energy and fundamental principal of the wind power are introduced in the first chapter of this bachelor thesis. The second chapter deals with the description of each part of wind turbine and the differences in their construction depending on individual needs. Third chapter presents problems and solutions of transportation and construction of wind turbines. Fundamental building and logistic mechanisms are also included. The last part of this bachelor thesis is focused on multi-rotor wind turbines which can represent the future in the wind power industry.
Aviation impact on global warming
Štarha, Adam ; Juračka, Jaroslav (referee) ; Zikmund, Pavel (advisor)
This bachelor‘s thesis deals with the issue of ever-increasing aviation emissions. It describes where greenhouse gases appear and what their excessive amount causes. Furthermore, this work deals with the comparison of emissions of individual modes of transport and the comparison of the benefits of individual modes of transport, especially air transport, through subsidies and tax relief in the EU.
The issue of parking in Nove Zamky
Vajda, Ronald ; Radimský, Michal (referee) ; Matuszková, Radka (advisor)
This bachelor’s thesis deals with the issue of static transport in the town of Nové Zámky. The subject of this work is the analysis of static transport in the city. The city was divided into individual logical zones. Deficiencies were found in the analytical part of the existing state, which were subsequently addressed in the design part. The proposed solutions for parking areas are partly designed to soak up water in the city and thus contribute to a better climate in the city.
Creation of Logistics Concept in a Business Organization with International Impact
Fojtíčková, Petra ; Ing.Petr Jašek (referee) ; Jurová, Marie (advisor)
The diploma thesis deals with the logistics concept in a selected company with a focus on distribution channels in international trade. The theoretical part of the work is focused on clarifying the concepts that are related to the issue. The analytical part is focused on the analysis of distribution with a focus on distribution channels to the individual countries in which it operates. In the last part of the work, based on the obtained and analyzed data, own proposals for solving the identified shortcomings are proposed.
Study of Creating a Logistics Concept in a Selected Company
Bobotová, Michaela ; Bartoš, Peter (referee) ; Jurová, Marie (advisor)
The diploma thesis discusses the study of creation of new logistics conception and its proposal for the company, Schaeffler Skalica, spol. s r. o., which is engaged in the production of bearings and components for the automotive industry. The proposal of the new logistics conception relates to the stocks of Schaeffler Skalica, spol. s r. o., which are stored in the consignment warehouse in Germany and are supplied by Chinese supplier.
Weather recognition from camera images/sequences
Sadel, Juraj ; Honec, Peter (referee) ; Janáková, Ilona (advisor)
The aim of my master's thesis is to design and then implement suitable weather classification algorithms mainly focused on the detection of precipitation and fog, including parameterization. The first half of my thesis is devoted to a theoretical description of weather and it's impact on transport. Furthermore, the theory of image processing and neural networks and already existing solutions is approached. Subsequently, the used datasets are described. The practical part of thesis is devoted to the design of possible algorithms based on the theoretical part of the thesis. After the design, the individual algorithms are implemented, tested and evaluated. Finally, a comparison of classical methods and neural networks is described.
Role of drug transporters in placental transfer of entecavir
Lukášová, Veronika ; Červený, Lukáš (advisor) ; Hofman, Jakub (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Veronika Křečková Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Role of drug transporters in placental transfer of entecavir Entecavir (ETV), an analogue of guanosine, is a highly efficient anti-hepatitis B antiviral drug. It is the first-line therapy for both adults and children. Its use in pregnancy is limited due to a number of factors, including lack of data on placental pharmacokinetics. The placental transition of drugs is frequently controlled by drug transporters. ATP-binding (ABC) transporters, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) or multidrug resistance-associated protein 2 (MRP2) localized in the apical membrane of syncytiotrophoblast and pumping their substrates in the feto-maternal direction belong to most significant determinants of placental pharmacokinetics. Moreover placental transport of nucleoside-derived drugs can be affected by the activity of nucleoside transporters (NTs); equilibrative nucleoside transporters (ENTs) mediate facilitated diffussion, while the concentrative nucleoside transporters (CNTs) control active influx of their substrates. The aim of the diploma thesis was to describe the role of P-gp, BCRP, MRP2 and NTs (ENTs and...
Study of drug-drug interactions of antiviral drugs on intestinal transporters
Záboj, Zdeněk ; Červený, Lukáš (advisor) ; Vokřál, Ivan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Zdeněk Záboj Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Study of drugs interactions of antiviral drugs with intestinal transporters Sofosbuvir is an antiviral agent widely used in the treatment of chronic hepatitis C. This orally administered prodrug is a designed substrate of ATP-binding (ABC) efflux transporters, P- glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). ABCB1 and ABCG2 are important determinants of intestinal absorption and are the site of significant pharmacokinetic drug interactions, leading to changes in drug exposure. Pharmacokinetic drug interactions may be undesirable (increasing the toxicity of the treatment) or desirable (allowing dose reduction). Because sofosbuvir is often administered in combination regimens with other anti(retro)virotics, the aim of this thesis was to study the ability to enhance intestinal absorption of sofosbuvir. To study the pharmacokinetic drug interactions on ABCB1 and ABCG2, a widely established in vitro bi-directional transport method through a polarized monolayer formed by the Caco-2 cell line derived from colorectal cancer has been used. We analyzed the drug interactions of sofosbuvir on these efflux...
Arsenic toxicity and hyperaccumulation in plants and their potentail use in phytoremediation
Gímeš, Lukáš ; Mašková, Petra (advisor) ; Podlipná, Radka (referee)
Arsenic is classified as a heavy metalloid. Small amounts of arsenic can be found in the environment naturally, but human activity constantly increases the amount of arsenic in the soil. Increasing arsenic contamination of the soil causes serious health problems for both animals and humans. Due to its toxicity, it can also cause considerable problems for plants. Arsenic negatively affects a number of processes in the body of plants, such as oxidative stress or the metabolism of important macromolecules. Photosynthesis is a physiological process that is the most affected by arsenic toxicity. Closely related to photosynthesis are the growth properties of plants. Negative effects that arsenic has on many biochemical, physiological and morphological processes in the plant body, we must understand the uptake, translocation and detoxification of arsenic in the plant body. Arsenic hyperaccumulators are plants that can accumulate orders of magnitude higher concentrations of As and better manage the phytotoxicity of this contaminant than non-hyperaccumulating plants. Hyperaccumulation of heavy metals is associated with changes in the physiological properties of plants. A common characteristic of hyperaccumulators is that they can accumulate the higher concentrations of metals they in the aboveground parts...

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