National Repository of Grey Literature 53 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Vojta's reflex locomotion in hereditary polyneuropathies
Vinciková, Lenka ; Kobesová, Alena (advisor) ; Truc, Michal (referee)
CMT disease is the most frequently type of the hereditary polyneuropathy. In the Czech republic are some 2 - 4 thousand people with this disease. Clinical picture is characterized by deterioration peripheralnerves, that faces to muscular atrophy and mobility disorders. Lower limbs are affected early than upper limbs. On the lower extremitywe observe typical deformity progress - pes cavus. Fingers on the hand are in claw position. The disturbed peripheral nerves and foot deformity affect balance, movement and stability. The scope of my work was assessment of the value of the Vojta's reflective locomotion for the hereditary polyneutopathy. Powered by TCPDF (
Regulatory instruments of cycloturism in specially protected areas
Kostříková, Markéta ; Máca, Vojtěch (advisor) ; Kotecký, Vojtěch (referee)
Cyclotourism is one of the most popular recreational activities nowadays, and specially protected areas are often chosen as a preferred destination. This thesis covers the issues that can arise from excessive tourist use of the area, or by not complying with the rules set by the law, or by an administration of the protected area. Cyclotourism has a considerate impact on the environment. The most affected components are vegetation, soil, aquatic ecosystems, and animals located near trails. Regulatory instruments of cyclotourism in specially protected areas are analysed and compared in this thesis. This analysis has covered four European countries, the Czech Republic, Slovakia, Germany, and Austria. The lowest level of restrictions was found to be present in the Czech Republic, the highest on the other hand in Austria. The degradation of the environment caused by cyclotourism is examined in the practical section of this thesis. On cycling routes in 9 specially protected areas, segments were randomly selected for sensitivity assessment... Indicators of sensitivity were: presence of a water body, forest, tourist attraction, elevation change level, and geological subsoil. Segments with increased sensitivity were visited and evaluated. Out of total of 73 segments with increased sensitivity, degradation...
The role of sentinel lymph node biopsy in the management of patients with early-stage cervical cancer
Kocián, Roman ; Cibula, David (advisor) ; Roztočil, Aleš (referee) ; Špaček, Jiří (referee)
The sentinel lymph node biopsy is part of recommended surgical staging guidelines in patients with early stages of cervical cancer. High success rates of bilateral detection of SLN are achieved in sites with adequate experience with this procedure. The sentinel lymph node biopsy without systematic pelvic lymph node dissection is currently considered inadequate procedure for stages IB to IIA of the disease. One of the benefits of sentinel lymph node detection is extensive histopathological examination using the ultrastaging protocol enabling detection of small metastases (i.e. micrometastases). At the moment, there is lack of evidence about oncological safety of sentinel lymph node biopsy which might replace systematic lymph node dissection in the future. Prognostic significance of micrometastases is also controversial due to the lack of data about their potential presence in non-sentinel lymph nodes in cases with negative sentinel lymph nodes. This dissertation deals with the concept of sentinel lymph node biopsy in the cervical cancer and focuses on several topics. We have shown that the presence of micrometastasis is associated with significant negative impact on patients' prognosis on the largest retrospective cohort of patients ever published. Only 67% of patients with micrometastasis have...
Detection of surface phenotype and chemosensitivity in bladder carcinoma cells in vitro
Šímová, Michaela ; Drbal, Karel (advisor) ; Vondálová Blanářová, Olga (referee)
Tumor malignancies are the second leading cause of death worldwide. One of the reasons for the failure of oncological treatment are the uniformly set clinical guidelines, which neglect the effect of high intertumoral heterogeneity. The in vitro chemosensitivity and resistance (CSRA) assays allow for the stratification of patients prior to therapy. Therefore, the CSRA are a long-considered method for personalization of components of chemotherapy regime. Nevertheless, none of them is being routinely used in clinical practice. Certain chemotherapeutics used for their cytotoxic and cytostatic effect are also able to induce so-called immunogenic cell death (ICD) of tumor cells and activate an anti-tumor immune response. Monitoring of changes in the expression of molecules associated with the regulation of the innate immune system on the surface of dying tumor cells would enable to predict the patient's ability to respond to treatment involving modern immunotherapeutics. The feasibility of CSRA using flow cytometry and microscopy is critically evaluated in this thesis on a model of bladder cancer. Simultaneously, the correlation of the immunogenic phenotype of tumor cells and their sensitivity to selected chemotherapeutics is discussed.
Diagnosis of leishmaniases in humans and dogs
Černá, Eva ; Spitzová, Tatiana (advisor) ; Votýpka, Jan (referee)
Leishmaniasis is a serious disease caused by parasites that affects both people and animals. In people, this disease has three forms, cutaneous, mucocutaneous and visceral form. Visceral form is lethal if it's left untreated. Leismaniasis is usually diagnosed by using regular parasitological methods based on histocytological analysis. In the last few years, there has been a considerable progress in serological and molecular diagnostics. This thesis focuses on description and comparison of the traditional and the new diagnostic methods. Attention is paid primarily to the new methods, therefore serological and molecular. These methods are compared by their sensitivity, specifity, field application potential, financial costs and time consumption. Both human and canine diagnostics are mentioned due to the fact that dogs are a significant reservoir. Key words leishmaniasis, diagnostics, parasitology, humans, dogs, method, molecular, serological, sensitivity, specifity
Indikátory zranitelnosti dopravy změnou klimatu
Mertl, Jan
Příspěvek je věnován vyhodnocení zranitelnosti dopravy ČR projevy změny klimatu, a to na základě indikátorů zranitelnosti. Metodickým základem indikátorů zranitelnosti je koncept zranitelnosti rozlišující tři základní komponenty zranitelnosti – expozici, citlivost a adaptační kapacitu.
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Detection of QRS complexes in ECG signals
Zhorný, Lukáš ; Ronzhina, Marina (referee) ; Kozumplík, Jiří (advisor)
This thesis deals with the detection of QRS complexes from electrocardiograms using time-frequency analysis. Detection procedures are based on wavelet and Stockwell transform. The theoretical part describes the basics of electrocardiography, then introduces common approaches to time-frequency analysis, such as short-time Fourier transform (STFT), wavelet transform and Stockwell transform. These algorithms were tested on a set of electrograms from the MIT-BIH and CSE-MO1 arrhythmia database. For the CSE database worked best the method based on the wavelet transform with the filter bank Symlet4, with the resulting value of sensitivity 100 % and positive predictivity 99.86%. For the MIT database had the best performance the detector using the Stockwell transform with values of sensitivity 99.54% and positive predictivity 99.68%. The results were compared with the values of other authors mentioned in the text.
School support for pupils suffering from the loss of relatives
Zemanová, Kateřina ; Machovcová, Kateřina (advisor) ; Kučírek, Jiří (referee)
This diploma thesis is dealing with the methods teachers and school psychologist may use to approach their pupils who have been affected by the death of their relative, particularly a family member. The theoretical part of the thesis is focusing on the existing research in the area of mourning of school-age children and pays special attention to the risks connected with insensitive approach of teachers in this matter. The thesis tries to introduce some principles of the teacher's sensitive approach during the lessons, while paying extra attention to the personal and moral development of the individual in the area of their perception of surroundings, specifically during Civic Education and Health Education. The next topic in the theoretical part is the cognitive development of pupils and their view on the death itself in general, as it is a part of life that we have to somehow prepare for and thus need to have some kind of knowledge about the difficulties that come with death. The empirical part consists mainly of individual interviews with teachers and one school psychologist. As for the part of the interviews, analysis of study materials was included in which both their advantages and possible risks were considered. The aim of this thesis is mainly to formulate principles of the sensitive...
Analysis of uncertainties in the calculation of residual stresses
Dubravec, Kristián ; Houfek, Lubomír (referee) ; Návrat, Tomáš (advisor)
This thesis is about analysis of uncertainties in the calculation of residual stresses, which are homogeneous and measured by the hole-drilling method. Stochastic approach is explained using models of beams. Theory of residual stresses is included. Source code for evaluating residual stresses deterministically and stochastically is created using the Python language. Sensitivity analysis of input parameters is performed.
An examination (analysis) of susceptibilities to antibiotics of the strain Staphylococcus aureus performed by phenotypic methods in conventional microbiological laboratory and interpretation of its results.
The aim of bachelor´s thesis is the understanding and the correct interpretation of results of susceptibility to antibiotics of the strain Staphylococcus aureus from serious clinical materials as a hemoculture, a peritoneal fluid from joints and abscesses, a smear from wounds, tissues during infectious total artificial joints, samples of an urine, materials from the lower respiratory tract and another clinical samples. According to data which have been used, my aim also have been to prove or eventually disprove the first hypothesis, that makes sense to collect also hemocultures from patient whose result in the serious clinical material contained the strain of Staphylococcus aureus. Prove or disprove the second hypothesis that with the number of positive results of the strain of Staphylococcus aureus in samples of urine will be in the same time the most positive hemocultures in percentage in comparison with results of the strains of Staphylococcus aureus in other clinical materials. Defined targets were reached by regular practical education in the Department of Clinical Microbiology. I had adopted a methodology of examination of susceptibility in the department and then have practiced under the professional supervision. Before the practical part of my thesis, I have had to elaborate and learn theoretical part of it. In that part is deeply described the kind Staphylococcus aureus, antibiotical treatment of this strain and the list of mostly tested antibiotics in the routine microbiological laboratory. In the practical part of the thesis I am focusing on the determination of sensitivity to antibiotics by the disk diffusion method and a defining minimal inhibition concentration. I have interpreted results and for example, I have depicted mostly occurred antibiograms and equally less occurred or rare ones. Then I have processed results of sensitivity of Staphylococcus aureus. The examined set has been containing 588 samples of positive Staphylococcus aureus. 72 samples from the set have been MRSA positive. A representation of positive hemocultures has been examined too in currently or earlier found positive materials. Positive hemocultures in positive materials have been found in ca 5,2 % of all positive clinical materials. The most positive hemocultures were found in previous positive samples of urine ca 17 %. The second highest positivity of hemocultures was in samples from bones and joints ca 14 %. Then artificial materials ca 13 %, venous catheters ca 10 %, abscess ca 6 %, materials from respiratory tract ca 4 %, soft tissues ca 3 % and wounds ca 2 %. The significant gained finding and conclusion of the thesis is the fact that during serious staphylococcus infections the sampling of hemocultures is indicating as a necessity and as an obligation of the sampling of hemocultures of a patient is finding of the strain of Staphylococcus aureus in the sample of urine.

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