National Repository of Grey Literature 855 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
The role of Kit ligands in hematopoiesis of Danio rerio
Oltová, Jana
Hematopoiesis is a precisely regulated process, dependent on the activity of hematopoietic cytokines and their receptors. Due to an extra round of whole genome duplication in teleost fish, two paralogs of many important genes, including some hematopoietic cytokines and their receptors, are present in the zebrafish (Danio rerio) genome. In this project, we have been investigating the role of zebrafish Kit ligands in hematopoiesis. Kit ligand is a pleiotropic cytokine, which is essential for vertebrate erythropoiesis; however, in zebrafish, no such role has been reported so far. To determine the function of zebrafish paralogs of Kit ligand (Kitlga and Kitlgb) in hematopoiesis, we performed in vivo and ex vivo gain- and loss-of-function experiments. Strikingly, we were the first to report the synergistic cooperation of zebrafish Kitlga with erythropoietin and dexamethasone, enabling the growth of kidney marrow-derived suspension cells and providing optimal conditions for the expansion of adult erythroid progenitors. We assume that by using different cytokine combinations, optimal conditions for the growth of other hematopoietic cell types can be established, and therefore, this new approach now available for the...
Drug Information Centre service analysis IV. - drug interactions
Michálek, Georg ; Malá, Kateřina (advisor) ; Doseděl, Martin (referee)
Drug Information Centre service analysis IV. - drug interactions Author: Georg Michálek Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Drug information centre (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and University Hospital Hradec Králové was established in 1994. It provides drug information to healthcare professionals in the form of timely and accurate answers to drug-related enquiries, including drug interactions (DI). Aim: This study aimed to analyse enquiries related to DI processed by DIC from 2015 to 2020 and to solve three drug enquiries related to drug interactions. Methods: Quantitative and qualitative analysis of drug enquiries was carried out. Data was collected from individual enquiries related, but not limited to drug-drug, drug-herbal, and drug-disease interactions. The quantitative analysis based on descriptive statistical methods was performed on two levels: enquiry level and drug interaction level. On the enquiry level, ATC codes found in the enquiries were analysed and on the drug interaction level various parameters assigned to each DI were analysed, such as interacting components,...
Storage For Gpon Frames
Holik, Martin
This thesis deals with the principle of data storage from passive optical networks. The thesis contains a basic summary of differences between individual standards, but the work is primarily focused on the description of the principle of frame storage based on the GPON standard developed by the International Telecommunication Union – Telecommunication section (ITU-T), which is considered the most widespread.
Creation and analysis of in-house database of pyrazine derivatives with potential antimicrobial activity
Kebakuile, Legae Gomolemo Boemo ; Zitko, Jan (advisor) ; Kučerová, Marta (referee)
In the early phases of drug design and development, scientists must overcome many challenges involved in identifying potential drug-like or lead-like compounds. This has led to the need of creating large sets of chemical data which will aid in improving the identification of pharmacophores and active compounds. Various scientific fields especially pharmacology, medicinal chemistry and biochemistry have begun to employ the use of computer sciences to aid in the screening for potential leads with more specificity with regards to drug-like compounds' or substances' bioactivity. The emphasis of this project was to create a database containing a collection of pyrazine compounds synthesized overtime in the Faculty of Pharmacy (Charles University, Hradec Kralove) with the aim of having anti-mycobacterium (and possible antibacterial and antifungal) activity, and further utilize this database to predict certain pharmacokinetic and bioavailability properties. This project seeks to demonstrate how certain molecular descriptors can be used as reliable chemoinformation to determine the likeliness or possibility of developing a lead-like or drug-like compound by utilizing computer software. An in-house database of 623 compounds saved in SMILES format was created and used in demonstrating quantitative...
Service Design
Fišerová, Barbora ; Dědic, Filip (referee) ; Kubíková, Zuzana (advisor)
The diploma thesis describes the design of your own web application within the long-term collaborative project In a small team, we reflect on our own workflow and designer work. Currently, the common goal is the design and development of MVP for processing text, images and other graphic material into any graphic output - graphic editor As part of the project, we have also focused for a long time on the concept of compatible MVPs for text editing or data management and user research. The starting point of is the principle of DRY (Don't repeat yourself) and the principles of web technologies. We test how certain workflows can be automated and facilitate the collaboration of designers, text authors, editors, proofreaders, etc., or emancipate users from unnecessary activities.
Interactive Database for the Storage and Maintenance of the Biological Data
Dúbrava, Juraj Ondrej ; Martínek, Tomáš (referee) ; Musil, Miloš (advisor)
Cieľom tejto práce je vytvorenie novej databázy dát pre proteínovú stabilitu, ktorá bude udržiavať a poskytovať experimentálne dáta. Výsledkom práce je databáza FireProtDB, ktorá poskytuje manuálne overené experimentálne dáta z dostupných zdrojov a implementuje grafické užívateľské rozhranie, ktoré poskytuje dôležité informácie o dátach spoločne s možnosťou vyhľadávania umožňujúcim vytvárať dotazy na mieru a cieliacim na užívateľov, ktorí hľadajú dáta pre vytváranie dátových sád pre nástroje využívajúce strojové učenie.
Complex On-Line Training Diary
Kamenský, Zdeněk ; Hynek, Jiří (referee) ; Bartík, Vladimír (advisor)
Design and implementation of online training diary for athletes is the main goal of this thesis. At the beginning, it was necessary to explain some of key words, related to the thesis topic. One of the most important things is data mining and its usability for sports data analysis. After that, existing solutions of sport applications were analyzed and also it was obligatory to analyze potential users requirements. Application design, implementation and testing were the next steps. Some of data mining methods were used for analysis of sports data intended for individual athletes and their coaches.
Data Backup and Data Storages
Chytková, Markéta ; Kindlová, Dita (referee) ; Kříž, Jiří (advisor)
This bachelor thesis focuses on the problem of data backup in the company FOUL s.r.o., which offers football items. Bachelor thesis consists of three main parts, which are the theoretical basis, the analysis of the current state and the solution design. The output of this thesis is the design of a more efficient solution for data backup.
Extension Program Module for Database Server of Geotechnical Tests
Knoteková, Hana ; Luhan, Jan (referee) ; Kříž, Jiří (advisor)
In my bachelor thesis we focus on creating new functionalities in an existing database. Specifically, on the control of tests, samples and tasks. Creating a WEB interface. Design and prepare reports for the WEB interface. The aim of my bachelor thesis is to design a solution how I would like to perform a certain functionality from the customer solved.
Database Design for a Small Company
Horňák, Marek ; Novák, Lukáš (referee) ; Kříž, Jiří (advisor)
This bachelor thesis describes the design of relational database for a small company engaged in sales and authorized repairs of sensitive electronic devices. Main target of the database solution will be the support and increase of process efficiency focused mainly on device maintenance and its planning within the company. Thesis is composed of three consecutive parts. First part defines theoretical foundations needed for understanding the issue of data modeling. The second part deals with the analysis of a current state of the company. Data model, design of which is the matter of third part of this thesis, will be built on the outcome of analysis of the company and its internal processes. Thesis then contains evaluation and expected benefits for the company.

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