keywords:"Rho-kinase" - Search Results - Digital Repository

guest :: login Digital Repository
		Search		Submit		Help		About

Home > Search Results: keywords:"Rho-kinase"

Search:

Search Tips :: Advanced Search

Search collections:

Sort by:	Display results:	Output format:

	The role of RhoA/Rho kinase signalling pathway in the regulation of blood pressure in normotensive and hypertensive rats Brunová, Aneta ; Zicha, Josef (advisor) ; Wasková, Petra (referee) Evidence is accumulating that point to a major role of Rho kinase in arterial pathophysiology. Rho kinase is a key enzyme in calcium sensitization in vascular smooth muscle cells. Calcium sensitization is characterized as an increase in vascular contractility in the conditions of constant cytosolic calcium level. Inhibitors of Rho-kinase exert beneficial effects on the cardiovascular system, mainly by lowering vascular contractility. This thesis summarizes the current progress in understanding of the signaling pathways involved in the control of peripheral resistance of spontaneously hypertensive rats (SHR). It is evident that enhanced sympathetic activity and abnormal regulation of ion channel activity collectively contribute to high blood pressure maintenance in SHR. Detailed record
	The role of Rho-kinase signaling pathway in the regulation of blood pressure Brunová, Aneta ; Zicha, Josef (advisor) ; Kopkan, Libor (referee) Calcium sensitization represents a mechanism that enables vascular smooth muscle cells to change the sensitivity of the contractile apparatus to intracellular calcium The aim of this study was to determine to what extent is calcium sensitization modulated by the renin- angiotensin system (RAS), sympathetic nervous system (SNS), nitric oxide (NO) and prostanoids produced by cyclooxygenase (COX). For this purpose we studied the effects of acute and chronic blockade of particular systems on blood pressure changes elicited in conscious normotensive rats by administration of Rho-kinase inhibitor fasudil. Adult male chronically cannulated Wistar rats were used in all experiments. Main findings of this study are as follow: 1) Decrease of blood pressure elicited by Rho-kinase inhibition was enhanced under the conditions of acute NOS inhibition. Inhibition of NOS was shown to have a bigger effect than COX inhibition (this was confirmed under the conditions of acute RAS and SNS inhibition as well). These findings are in agreement with the hypothesis that NO exerts a suppressive effect on calcium sensitization. 2) Chronic NOS inhibition caused hypertension characterized by a more pronounced blood pressure lowering after Rho-kinase inhibition in comparison with control. NO chronically suppresses the calcium... Detailed record
	The role of RhoA/Rho kinase signalling pathway in the regulation of blood pressure in normotensive and hypertensive rats Brunová, Aneta ; Zicha, Josef (advisor) ; Wasková, Petra (referee) Evidence is accumulating that point to a major role of Rho kinase in arterial pathophysiology. Rho kinase is a key enzyme in calcium sensitization in vascular smooth muscle cells. Calcium sensitization is characterized as an increase in vascular contractility in the conditions of constant cytosolic calcium level. Inhibitors of Rho-kinase exert beneficial effects on the cardiovascular system, mainly by lowering vascular contractility. This thesis summarizes the current progress in understanding of the signaling pathways involved in the control of peripheral resistance of spontaneously hypertensive rats (SHR). It is evident that enhanced sympathetic activity and abnormal regulation of ion channel activity collectively contribute to high blood pressure maintenance in SHR. Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.

Digital Repository :: :: :: ::
Powered by v1.1.2
Maintained by

This site is also available in the following languages:
Česky English