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Placental transport of dopamine and norepinephrine
Turková, Helena ; Štaud, František (advisor) ; Jirkovský, Eduard (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Helena Turková Supervisor: prof. PharmDr. František Štaud, Ph.D. Title of diploma thesis: Placental transport of dopamine and norepinephrine During the whole course of pregnancy, it is important to maintain proper monoamine homeostasis, namely serotonin (5-HT), norepinephrine (NE), and dopamine (DA), which are crucial for proper placental function and fetal development. Monoamines are important neuromodulators, involved in cell proliferation, and differentiation. and neuronal migration. High fetal monoamine secretion during gestation demands a responsible clearance mechanism, as disruption of their balance may lead to long-lasting changes in brain structure and function, provoking a higher risk of attention deficit hyperactivity disorder (ADHD), autism or depression. However, uptake of NE a DA through the fetoplacental unit has not been fully and in detail described. Therefore, in this diploma thesis, we focus on the uptake of NE and DA through ex vivo isolated vesicles of microvillous (MVM) and basal (BM) membranes from healthy human term placentas. Our results show that NE and DA uptake is mediated via high-affinity and low-capacity serotonin (SERT) and norepinephrine (NET) transporters in...
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Placental transport of dopamine and norepinephrine
Turková, Helena ; Štaud, František (advisor) ; Jirkovský, Eduard (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Helena Turková Supervisor: prof. PharmDr. František Štaud, Ph.D. Title of diploma thesis: Placental transport of dopamine and norepinephrine During the whole course of pregnancy, it is important to maintain proper monoamine homeostasis, namely serotonin (5-HT), norepinephrine (NE), and dopamine (DA), which are crucial for proper placental function and fetal development. Monoamines are important neuromodulators, involved in cell proliferation, and differentiation. and neuronal migration. High fetal monoamine secretion during gestation demands a responsible clearance mechanism, as disruption of their balance may lead to long-lasting changes in brain structure and function, provoking a higher risk of attention deficit hyperactivity disorder (ADHD), autism or depression. However, uptake of NE a DA through the fetoplacental unit has not been fully and in detail described. Therefore, in this diploma thesis, we focus on the uptake of NE and DA through ex vivo isolated vesicles of microvillous (MVM) and basal (BM) membranes from healthy human term placentas. Our results show that NE and DA uptake is mediated via high-affinity and low-capacity serotonin (SERT) and norepinephrine (NET) transporters in...
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The value and use of member?s memories due to providing on-site social services for seniors in Regional charity Strakonice
TURKOVÁ, Helena
The thesis deals with the importance and possibilities of using memories in social services with seniors. Thesis is divided into two main parts. The first part contains the theoretical knowledge of the senior age, the value of memories in social services with seniors and methods of social services that are focused on the use of memories. The second part targets on the qualitative research of the problem in a specific organization aimed at providing the field of social services for the seniors, the Regional Charity Strakonice, in nursing service and personal assistance. The research is focused on the analysis of the importance of memories in terms of employees and users in providing on-site social services, evaluation methods of work with memories and to consider options for further use of methods of work with the memories in this organization.
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The Creation of a School Curriculum for preschool Education
TURKOVÁ-KUBÁTOVÁ, Helena
The aim of my work is to confirm the benefits of the creation of the school curriculum and to improve the education in the particular kindergarten. The theoretical part contains a starting point of the current preschool education, the school curriculum and principles and progressive steps of the creation of the school curriculum. In the practical part a student checks the consecutive steps in her workplace. She qualifies the appropriateness of certain teamwork techniques which were recomended in the literature and describes a particular course of the creation and the program´s impact on education in the kindergarten. The final school curriculum for preschool education is a part of this work.
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Influence European agricultural fund for rural development(EAFRD) and on increasing developing potential of Sušice region
TURKOVÁ, Helena
Major goals those graduation these is pass judgment on to what degree has European agricultural fund for rural development influence on increasing developing potential in the concrete region Sušicko. The theoretical part of this thesis describes the basic concepts, such as structural policy, programming period, the common agricultural policy and of course the European Agricultural Fund for Rural Development. There is generally characterized Sušický region in terms of population, economy, economic activities, infrastructure and environment. Particular attention is paid to agriculture in this area. In the last chapter of the practical part are 2 model examples. In diploma work I followed the following points: 1. Preparation of a literature retrieval; 2. Information Collection; 3. Questionnaire survey; 4. Analysis of the information; 5. Synthesis and evaluation of results; 6. Processing model examples.
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The Bilance and Her Predicative Abilities
TURKOVÁ, Helena
The main goal of my work is examination of predicative abilities basic account sheet {--} balance-sheet in light of economic feature of acount entity Madeta, a.s. For better predicative abilities is used finacial analysis and any other completive indicators. So we need the second account sheet yet - profit and loss accounts. For the analysis were selected the years 2001 - 2006. This work is split to the 2 parts {--} in the first is describe balance sheet and her elements, profit and loss accounts and finacial analysis. This analysis contain a indicators of profitability, indicators of activity, indebtedness and liquidity. As others are there mentioned indicators productivity of labour and regression and correlation analysis. In the second part is the analysis applied at the concrete company. During the selection and using of these coefficients it was necessary to take account of the specific content of account sheets. For the illustration are created graphs.
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