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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
The use of animal models in the study of pathogenesis of Bordetella pertussis
 Traganová, Veronika ; Holubová, Jana (advisor) ; Lichá, Irena (referee)
Bordetella pertussis is a strictly human pathogen and a causative agent of whooping cough. The study of bacterial transmission, virulence factors and vaccine efficacy testing became a very relevant topic, due to the disease resurgence in well-vaccinated populations during the past decades. Detailed investigation of bacterial interactions in vivo requires a suitable animal model. The most common used animal for B. pertussis testing is a laboratory mouse, however mice are unable to develop the typical B. pertussis infection symptomps. In the field of vaccine research and testing, the newborn pig has also proved to be a suitable model. By far the best nonhuman host of B. pertussis is the recently discovered baboon model which can perfectly imitate the human respiratory tract conditions, immune response and also the host-to-host transmission. This thesis summarizes basic knowledge of model organisms used in the past and in the present for the study of B. pertussis. At the same time, it shows the comparison of the advantages and disadvantages of the discussed animal models.
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