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Boron cluster conjugates as building blocks for the preparation of polymeric nanostructures
Steiner, Filip ; Matějíček, Pavel (advisor) ; Ďorďovič, Vladimír (referee)
Charles University in Prague Faculty of Science Department of Physical and Macromolecular Chemistry Author: Bc. Filip Steiner Supervisor: prof. RNDr. Pavel Matějíček, Ph.D. Advisor: Ing. Mariusz Uchman, Ph.D. Title: Boron Cluster Conjugates as Building Blocks for the Preparation of Polymeric Nanostructures Abstract This diploma thesis investigates the synthesis and supramolecular behaviour of amphiphilic conjugates of closo-dodecaborate dianion, [B12H12]2- , with polycationic diblock copolymer poly(ethylene oxide)-block-poly(2-(N, N, N', N'-tetramethyl guanidium ethyl acrylate), PEOn-b-PGEAm. The boron cluster dumbbells were synthesised by the exoskeletal, electrophile-induced nucleophilic substitution (EINS) and by subsequently ring-opening reaction with various aliphatic diols, resulting in a hybrid dumbbell molecule. These molecules were used for preparation of nanoparticles by co- assembly with polycationic diblock copolymer in water. Resulted nanostructures were characterised by static and dynamic light scattering and NMR spectroscopy. Keywords: boron cluster compounds, polymeric nanoparticles, co-assembly, NMR, light scattering
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Boron cluster compounds as building blocks in supramolecular chemistry
Steiner, Filip ; Matějíček, Pavel (advisor) ; Strachota, Adam (referee)
The aim of this bachelor thesis was to get used to with the basics of boron chemistry, especially the exoskeletal derivatization of boron cluster compounds. Exoskeletal substitution of the closo-dodecaborate anion [B12H12]2- , which proceeds by the electrophile induced nucleophilic substitution (EINS) mechanism, provided a derivative containing a cyclic oxonium ring which was subsequently opened by reaction with alcohols (1-dodecanol, 1-octanol). The prepared compounds were characterized by 1 H, 13 C and 11 B NMR spectroscopy and MALDI-TOF mass spectrometry. The compounds will be used as building blocks for preparation of novel nanostructures via supramolecular chemistry approaches.
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