|
|
Pharmacogenetics of peroral antidiabetics
Sichingerová, Ema ; Šeda, Ondřej (advisor) ; Včelák, Josef (referee)
Diabetes mellitus is a summarizing term for chronic metabolic diseases characterized by long- lasting hyperglycemia. The incidence of type 2 diabetes mellitus is rising worldwide, with the predominant characteristics of a global epidemic in recent years. Treatment of diabetes comprises, among other means, oral antidiabetics, whose function and incidence of side effects can also be influenced by genetic factors. Pharmacogenetics, a field on the border between pharmacology and genetics, deals with such interactions. Pharmacogenetic knowledge helps with drug development and deepens the understanding of the physiological causes of the disease, emphasizing the individuality of the patient. This thesis aims to summarize the pharmacogenetic interactions described in the most used oral antidiabetics so far and their mechanisms of action. Key words: pharmacogenetics, diabetes, gene-environment interactions, single nucleotide polymorphisms
|
guest ::
