Home > Search Results: Rudá-Kučerová, J.
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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Aripiprazole-induced adverse metabolic alterations in a polyI:C neurodevelopmental model of schizophrenia in rats
 Horská, K. ; Rudá-Kučerová, J. ; Dražanová, Eva ; Pistovčáková, J. ; Karpíšek, M. ; Kotolová, H. ; Demlová, R. ; Kašpárek, T.
The aim of this study was to evaluate metabolic phenotype of poly I:C rat model and asses metabolic effects of chronic aripiprazole treatment with regard to complex neuroendocrine regulations of energy homeostasis. Altered lipid profile in poly I:C model was observed. Leptin and GLP-1 serum levels were significantly reduced, while ghrelin level was elevated. Our data indicate that dysregulation of adipose tissue endocrine function and gastrointestinal hormones is implicated in metabolic adverse effects of antipsychotics.
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The influence of acute and chronic application of olanzapine on brain perfusion in rat
 Dražanová, Eva ; Rudá-Kučerová, J. ; Krátká, Lucie ; Horská, K. ; Kotolová, H. ; Štark, T. ; Babinská, Z. ; Micale, V. ; Starčuk jr., Zenon
Olanzapine belongs to the first choice drug in treatment of schizophrenia. We focused on blood perfusion changes inducted by acute and chronic application of olanzapine in healthy animals and MAM altered animals. We detectet significant lower perfusion of cerebral cortex in acute and chronic olanzapine treated animals. We susspect that it could be due to altered neurotransmiter regulation caused by olanzapine.
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