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Phytoremediation of nitro compounds: a toxicity of dinitrotoluene and a change in proteom of plants.
Pospíšilová, Blanka ; Skálová, Lenka (advisor) ; Szotáková, Barbora (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Mgr. Blanka Pospíšilová Supervisor: Prof. RNDr. Lenka Skálová, Ph.D. Specialized supervisor: RNDr. Radka Podlipná, Ph.D. Title of rigorous thesis: Phytoremediation of nitro compounds: a toxicity of dinitrotoluene and a change in proteom of plants. Nitro compounds present in the soil, the water and the air have been a considerable environmental burden for many years. For example 2,4-dinitrotoluene (2,4-DNT), used mainly as an explosive, belongs to hazardous chemicals and common environmental contaminants. Therefore, there is a need to develop new and effective methods of a removal of 2,4-DNT from the environment. A suitable method could be a phytoremediation which uses plants for removing pollutants directly from contaminated areas. It also minimizes the introduction of other chemicals into a decontaminating process. The aim of this work is to study the potential of plants to remove 2,4-DNT from contaminated water. Firstly, we focused on the ability of plants to metabolize 2,4-DNT. The degradation products: 2-aminonitrotoluen (2-ANT) and 4-aminonitrotoluen (4-ANT) were found both in media and plant extracts of suspension culture of Saponaria officinalis L. and Phragmites australis (Cav.)...
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The role of Wnt pathway in nociception
Pospíšilová, Blanka ; Skálová, Lenka (advisor) ; Pávek, Petr (referee)
Charles University in Prague University Roma Tre Faculty of Pharmacy in Hradec Králové Department of Biology Department of Biochemical Sciences Candidate: Veronika Staňková Supervisor: PharmDr. Iva Boušová, Ph.D. Prof. Sandra Incerpi, Prof. Jens Z. Pedersen, Prof. Luciano Saso Title of diploma thesis: Biological activity of antioxidant compounds in L-6 myoblasts from rat skeletal muscles. This work was carried out in the laboratory of physiology at University Roma Tre in Rome, under the supervision of Prof. Sandra Incerpi. The team of this laboratory studies the antioxidants of different structures and evaluates their ability to prevent the production of reactive oxygen species and oxidative stress. The reactive oxygen and nitrogen species play an important role as regulatory mediators of physiological responses. However, they can be also very harmful because they can damage DNA and proteins, cause peroxidation of lipids and injure other biomoleculs. In my work, I tested the antioxidant effect of different polyphenols (baicalein, 5,6-dihydroxyflavone, negletein, mosloflavone, gallic acid and its derivative) in the cell culture (L-6 myoblasts from rat skeletal muscles) and in the in vitro test. The state of oxidative stress was induced by cumene hydroperoxide (generator of cumene hydroperoxide...
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Phytoremediation of nitro compounds: a toxicity of dinitrotoluene and a change in proteom of plants.
Pospíšilová, Blanka ; Skálová, Lenka (advisor) ; Szotáková, Barbora (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Mgr. Blanka Pospíšilová Supervisor: Prof. RNDr. Lenka Skálová, Ph.D. Specialized supervisor: RNDr. Radka Podlipná, Ph.D. Title of rigorous thesis: Phytoremediation of nitro compounds: a toxicity of dinitrotoluene and a change in proteom of plants. Nitro compounds present in the soil, the water and the air have been a considerable environmental burden for many years. For example 2,4-dinitrotoluene (2,4-DNT), used mainly as an explosive, belongs to hazardous chemicals and common environmental contaminants. Therefore, there is a need to develop new and effective methods of a removal of 2,4-DNT from the environment. A suitable method could be a phytoremediation which uses plants for removing pollutants directly from contaminated areas. It also minimizes the introduction of other chemicals into a decontaminating process. The aim of this work is to study the potential of plants to remove 2,4-DNT from contaminated water. Firstly, we focused on the ability of plants to metabolize 2,4-DNT. The degradation products: 2-aminonitrotoluen (2-ANT) and 4-aminonitrotoluen (4-ANT) were found both in media and plant extracts of suspension culture of Saponaria officinalis L. and Phragmites australis (Cav.)...
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