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Controversies in Assessment of Surgical Safety Margins in Oral Squamous Cell Carcinoma
Pošta, Petr ; Hauer, Lukáš (advisor) ; Mottl, Radovan (referee) ; Pink, Richard (referee)
Oral squamous cell carcinoma (OSCC) is a serious and relatively common disease of the oral cavity. Radical surgical removal of the tumor currently remains the treatment of choice. Leaving residual tumor cells in the patient's body has a clearly negative prognostic effect. The key to the success of this treatment modality is the accurate determination of the extent of the tumor and the determination of the safe surgical margin of tumor resection. For this purpose, additional investigative techniques are used, further researched and newly developed to identify the extent of the presence of tumor-altered cells. The benefit of pre- and intraoperative use of natural autofluorescence was investigated in the presented research. The essence of our research is the hypothesis that the use of natural autofluorescence, specifically the VELscope (Visually Enhanced Lesion Scope) system, will lead to an increase in the success of surgical therapy in terms of achieving a tumor cell-free resection margin. The total number of 122 patients with a diagnosis of OSCC included in our study were divided after meeting the inclusion criteria by simple randomization into study and control groups. Before surgery, each patient from the study group was examined with a VELscope device together with marking the extent of...
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Orbital Floor Fractures
Mottl, Radovan ; Šimůnek, Antonín (advisor) ; Hauer, Lukáš (referee) ; Pink, Richard (referee)
Summary: Orbital floor fractures This work aimed to assess the impact of the implant material, the size of the defect, and the type of fracture on postoperative complications of surgically treated base orbit fractures. The monitored complications were enophthalmos, diplopia, innervation disorders of the infraorbital nerve. A total of 67 patients with "pure" and "impure" orbital fractures were enrolled in this study. The patients were examined, indicated for surgery, and operated at the Dentistry Clinic of the University Hospital in Hradec Kralove at the Department of Oral, Maxillofacial and Facial Surgery between 2009 and 2020. The group of patients included 41 men and 26 women. In the study, we compared several types of implant materials, i.e., 0.5 mm thick poly-p- dioxanone PDS foil (Ethicon, Johnson & Johnson, Germany), 0.4 mm thick titanium mesh (Synthes GmbH, Oberdorf, Switzerland), 1.5 mm thick Medpor (Porex Surgical Products Group, Newnan, USA), an individually made Toman column, and a Foley catheter balloon filled with saline. This study showed that the use of titanium mesh for the reconstruction of the orbit base led to a higher incidence of innervation disorders in the infraorbital nerve area (p=0.0245), compared to the use of other implant materials. Furthermore, a difference in the incidence of...
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